Scale-up of green synthesis and characterization of silver nanoparticles using ethanol extract of Plantago major L. leaf and its antibacterial potential
| Main Authors: | Sukweenadhi, Johan, Setiawan, Kezia Irianti, Avanti, Christina, Kartini, Kartini, Rupa, Esrat Jahan, Yang, Deok-Chun |
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| Format: | Article PeerReviewed application/pdf |
| Bahasa: | eng |
| Terbitan: |
Elsevier BV
, 2021
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| Subjects: | |
| Online Access: |
http://repository.ubaya.ac.id/39839/ https://www.sciencedirect.com/journal/south-african-journal-of-chemical-engineering |
Daftar Isi:
- Green synthesis of silver nanoparticles (Ag NPs) utilizing plant extracts has been widely optimized these days because of its eco-friendly, simple, and cost-effective manner. This present study was performed to evaluate the scale-up trial on synthesis parameter and centrifugation duration of Plantago major L. leaf ethanolic extract in the green synthesis of Ag NPs. Leaf extract concentration of 0.25%, 70 ◦C of temperature, 60 min of synthesis time, and 30 min of centrifugation time were concluded as the optimized scale-up condition of green synthesis. The scale-up trial resulted in spherical silver nanoparticles with an average size 12.2±5.11 nm, proven from various spectroscopic (UV–Vis, EDS, FTIR), microscopic observations (SEM, FE-TEM), and other observations (SAED, DLS, XRD). The synthesized Ag NPs also exhibit promising antibacterial activity against several tested bacteria at 20 μg mL− 1 of dosage. This study offers nine times higher yield of the synthesized Ag NPs (107.2±6.82 mg) at about the same making time of smaller scale of green synthesis. Sufficient nanoparticles will provide flexibility to carry out its characterization in an efficient manner and further bioactivity test and/or formulation experiments, such as in cosmetics, medical ointments, and other pharmaceutical products.