GREEN SYNTHESIS SILVER NANOPARTICLES FOR TOPICAL DIABETIC WOUND HEALING: SELECTION OF POTENTIAL INDONESIAN PLANT EXTRACTS FOR ANTIOXIDANT
| Main Authors: | Kartini, Kartini, Setiawan, Finna, Sukweenadhi, Johan, Yunita, Oeke , Avanti, Christina |
|---|---|
| Format: | Proceeding PeerReviewed application/pdf |
| Terbitan: |
, 2019
|
| Subjects: | |
| Online Access: |
http://repository.ubaya.ac.id/36169/2/ICOBIO%2D2019%2DAbstract%2DKartini%20et%20al.pdf http://repository.ubaya.ac.id/36169/ |
Daftar Isi:
- Impaired wound healing in diabetic patients is a serious complication that can lead to amputation and even death. Antibacterial and antioxidant herbs are potential candidates for diabetic wound healing agents. Silver nanoparticles are able to improve the activity of antibacterial and antioxidant agents. This study was conducted to select Indonesian plants having potency as antioxidant. This is an initial step to find plant candidates to be further developed as silver nanoparticles for diabetic wound healing. A total of 8 Indonesian medicinal plants (Orthosipon stamineus, Curcuma domestica, Curcuma xanthorriza, Phyllanthus niruri, Sonchus arvensis, Apium graveolens, Centella asiatica, and Stelechocarpus burahol) were extracted with ethanol and their antioxidant activity was determined using DPPH free radical scavenging method. Moreover, their chemical constituents was screened and their total phenolics and flavonoids was determined as well. Phyllanthus niruri showed the highest antioxidant activity with IC50 value of 108 ppm, followed by O. Stamineus, C. Domestica, Stelechocarpus burahol, and C. Xanthorriza with the IC50 value of 133, 365, 446, and 525 ppm, respectively. S. Arvensis, A. graveolens, and C. Asiatica showed weak antioxidant activity with IC50 value 1000 ppm. Phytochemical screening exhibited that herbs contain various chemical compound including essential oils, alkaloids, terpenoids, curcuminoids, poliphenols, and flavonoids. Total phenolic and flavonoids contents from the highest is as follow: P. niruri > O. Stamineus > C. Domestica > S. burahol > C. Xanthorriza > S. Arvensis > A. graveolens > C. Asiatica. P. niruri was the best candidate to be developed as silver nanoparticles for diabetic wound healing.