PREPARATION AND EVALUATION OF ATENOLOL-β-CYCLODEXTRIN ORALLY DISINTEGRATING TABLETS USING CO-PROCESS CROSPOVIDONE-SODIUM STARCH GLYCOLATE
| Main Authors: | Parfati, Nani, Rani, Karina Citra, Charles , Nathanael, Geovanny, Valencia |
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| Format: | Article PeerReviewed application/pdf |
| Terbitan: |
https://innovareacademics.in/journals/index.php/ijap/issue/view/Vol10Issue5
, 2018
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| Subjects: | |
| Online Access: |
http://repository.ubaya.ac.id/32880/7/PREPARATION%20AND%20EVALUATION%20OF%20ATENOLOL%2DfJ%2DCYCLODEXTRIN%20ORALLY_Nani%20Parfati.pdf https://innovareacademics.in/journals/index.php/ijap/issue/view/Vol10Issue5 http://repository.ubaya.ac.id/32880/ |
Daftar Isi:
- Objective: The aim of this current research was to formulate and analyze the characteristics of atenolol-p-cyclodextrin which using co-process crospovidone-sodium starch glycolate as the disintegrants. Evaluation which has been conducted on orally disintegrating tablets consist of wetting time, water absorption ratio, in vitro dispersion time, and dissolution. Methods: Inclusion complex of atenolol-p-cyclodextrin which were prepared using solvent evaporation method, then formulated using co-processed crospovidone-sodium starch glycolate 1:1 (formula 1) and 1 :2 (formula 2) into orally disintegrating tablets by direct compression technique. Orally disintegrating tablets of atenolol-P-cyclodextrin using a physical mixture of crospovidone-sodium starch glycolate 1:1 (formula 3), 1:2 (formula 4) was also prepared as a control. The prepared formulations (Fl-F4) were evaluated by several parameters such as wetting time, water absorption ratio, in vitro dispersion time, and dissolution. Results: Orally disintegrating tablets of atenolol P-cyclodextrin using co-processed crospovidone-sodium starch glycolate 1:1 (formula 1) showed shorter wetting time (53.53 ± 2.26 seconds) and in vitro dispersion time (47.44 ± 2.49 seconds) compare to the other formulas. Formula 1 also exhibited the highest dissolution efficiency compare to the formula which was used in the physical mixture. The results of this study also revealed that there was a high correlation between in vitro dispersion time and dissolution efficiency of atenolol-p-cyclodextrin orally disintegrating tablets. Conclusion: Orally disintegrating tablets of atenolol- P-cyclodextrin showed enhanced dissolution efficiency due to the presence of inclusion complex and co-processed crospovidonesodium starch glycolate. Formula 1 was found to be the best formula in this study. This formula effectively reduces in vitro dispersion time, hence the dissolution efficiency became higher.