Formulation and Characterization of Atenolol-β-Cyclodextrin Orally Disintegrating Tablets
| Main Authors: | Rani, Karina Citra, Parfati, Nani, ., Stephanie |
|---|---|
| Format: | Proceeding PeerReviewed application/pdf |
| Terbitan: |
, 2017
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| Subjects: | |
| Online Access: |
http://repository.ubaya.ac.id/31727/1/KARINA%20CITRA%20RANI%20%2D%20UBAYA.pdf http://repository.ubaya.ac.id/31727/ |
Daftar Isi:
- Atenolol is a competitive beta (1) -selective adrenergic antagonists and has been widely used in hypertension therapy. Atenolol has a low solubility characteristic in water and gastric fluid. For poorly soluble orally administered drugs, the rate of absorption is often controlled by the rate of dissolution. In this study, the solubility of atenolol has been increased by inclusion complex using β-cyclodextrin made by several methods (physical mixture, kneading, and solvent evaporation). Evaluation and characterization of atenolol-β-cyclodextrin inclusion complex consists of drug content, dissolution study, Fourier Transformed Infrared analysis (FT-IR), Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD), and Scanning Electron Microscope (SEM). The results of the drug content analysis, dissolution test, and characterization showed that atenolol- β-cyclodextrin inclusion complex, which has been made by solvent evaporation method was the best composition. Therefore, a solvent evaporation method was chosen to prepare orally disintegrating tablets of atenolol-β-cyclodextrin using direct compression technique. Orally disintegrating tablets of atenolol-β-cyclodextrin were prepared using crospovidone as disintegrant. The results of pre-compression test and post-compression test revealed that orally disintegrating tablets of atenolol-β-cyclodextrin inclusion complex had good physicochemical characteristics and met quality requirements.