Effects of Plantago major extracts and its chemical compounds on proliferation of cancer cells and cytokines production of lipopolysaccharide-activated THP-1 macrophages
| Main Authors: | ., Kartini, Piyaviriyakul, Suratsawadee , Thongpraditchote, Suchitra , Siripong, Pongpun , Vallisuta, Omboon |
|---|---|
| Format: | Article PeerReviewed application/pdf |
| Terbitan: |
Wolters Kluwer - Medknow Publications and Media Pvt. Ltd, Mumbai, INDIA
, 2017
|
| Subjects: | |
| Online Access: |
http://repository.ubaya.ac.id/30401/24/Effects%20of%20Plantago%20Major%20Extracts_2017.pdf http://www.phcog.com/ http://repository.ubaya.ac.id/30401/ |
Daftar Isi:
- Background: Plantago major has been reported to have anticancer and anti-inflammatory properties. However, its antiproliferative and anti-inflammatory mechanisms have not elucidated. Moreover, which plant parts are more suitable as starting materials has not been explored. Objectives: To investigate the antiproliferative activity of P. major MCF-7, MDA-MB-231, HeLaS3, A549, and KB cancer cell lines as well as their effects on inflammatory cytokines (tumor necrosis factor [TNF]-a, interleukin [IL]-1β, IL-6, an [IFN]-g) production by lipopolysaccharide (LPS)-stimulated THP-1 macrophages. Materials and Methods: The methanol and aqueous extracts of P. major from different plant its chemical compounds, i.e., ursolic acid (UA), oleanolic acid (OA), and aucubin were tested in this experiment. Results: Methanol and aqueous extracts of P. major greatest antiproliferative activity. The methanol extracts of seeds also demonstrated the highest inhibition of TNF-a, IL-1β, IL-6, and IFN-g production. Interestingly, t commonly discarded, exhibited comparable activities to those of leaves and petioles. Furthermore, UA exhibited stronger activities than OA and aucubin. Conclusions: being proposed as the main source for further development of anticancer and anti-inflammatory products, whereas the roots could be included in the preparation of products with respect to anti-inflammatory.