EKSTRAK ETANOL UMBI UBI JALAR UNGU (Ipomoea batatas L) MENINGKATKAN KETEBALAN MIOMETRIUM & JUMLAH KELENJAR ENDOMETRIUM
| Main Authors: | Citra Udiyani, Desak Putu, Jawi, I Made, Sugiritama, Wayan, Nyoman Arijana, I Gusti Kamasan |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Universitas Udayana
, 2021
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| Online Access: |
https://ojs.unud.ac.id/index.php/eum/article/view/79199 https://ojs.unud.ac.id/index.php/eum/article/view/79199/41820 |
Daftar Isi:
- Menopause merupakan proses fisiologis Wanita, namun dengan terapi Hormone Replacement Therapy (HRT) menimbulkan efek endometriosis dan tromboemboli vena. Umbi ubi jalar ungu (Ipomoea batatas L merupakan tumbuhan dengan antosianin. Antosianin mampu meningkatkan ketebalan miometrium dan jumlah kelenjar endometrium. Tujuan penelitian: penelitian ini membuktikan ekstrak etanol umbi ubi jalar ungu (Ipomoea batatas L) mampu meningkatkan ketebalan miometrium dan jumlah kelenjar endometrium uterus. Metoda penelitian: peneliaian dilakukan dengan rancangan penelitian True Experimental-Post Test Only Control Group Design dengan 28 ekor tikus betina Wistar dibagi 4 kelompok (@7 ekor tikus): kelompok kontrol (P0), esktrak etanol umbi ubi jalar ungu dosis 10 mg/kgBB (P1), 30 mg/kgBB (P2), dan 100 mg/kgBB (P3) diberikan selama 30 hari melalui sonde, hari ke 30 dilakukan pengangkatan uterus dan dan melihat ketebalan miometrium dan jumlah kelenjar endometrium uterus diamati secara histologi.Hasil penelitian menunjukkan bahwa: Rerata ketebalan miometrium uterus antar kelompok perlakuan berbeda secara statistik (signifikansi p=0,000). Ketebalan miometrium paling tinggi pada kelompok P3. Rerata jumlah kelenjar endometrium antar kelompok perlakuan berbeda secara statistik (signifikan dengan p=0,000) dengan jumlah kelenjar endometrium yang paling tinggi pada kelompok P3. Kesimpulan: hasil penelitian ini menyimpulkan ekstrak etanol umbi ubi jalar ungu dapat meningkatkan ketebalan miometrium dan jumlah kelenjar endometrium uterus tikus putih yang diovariektomi. Kata kunci: Ekstrak, ubi jalar ungu, antosianin, uterus
- Menopause is women’s physiological process, can treat by Hormone Replacement Therapy (HRT). Some adverse effects by HRT: endometriosis, venous thromboembolism. Purple sweet potato tubers (Ipomoea batatas L) are plants with anthocyanin. Anthocyanin therapy increases the myometrium thickness and number of uterine endometrial gland. This research to prove the ethanol extract of purple sweet potato tuber (Ipomoea batatas L) able to increase the myometrium thickness and the number of uterine endometrium gland. This study used the Post Test Only Control Group Design with samples of 28 Wistar female rats were divided into 4 groups (@7 rats). The groups were control group (P0); 10 mg/kgBW of ethanol extract of purple sweet potato tubers group (P1); 30 mg/kgBW (P2); and 100 mg/kgBW (P3) administered orally for 30 days through sonde. On day 30th the uterus is removed and uterus histologic preparation are made. The thickness of the myometrium and the number of endometrial glands were observed histologically by HE staining. The results showed that: the average thickness of the uterine myometrium between groups was statistically different (p=0.000). The highest thickness was P3. The average number of endometrial glands between groups was statistically significant (p=0.000) with the highest amount was P3. By the findings of this study, we concluded that ethanol extract of purple sweet potato tubers could increase the myometrium thickness and the amount of the uterine endometrial gland on ovariectomized white rats. Keywords: Extract, Purple sweet potato, anthocyanin, uterus