PENGARUH PERLAKUAN JUS KUBIS BUNGA (BRASSICA OLERACEA L. VAR BOTRYTIS L.) TERHADAP AKTIVITAS DIKLOFENAK DALAM TERAPI INFLAMASI PADA TIKUS PUTIH JANTAN GALUR WISTAR
| Main Author: | Endang Sri Sunarsih, Dwi Hadi Setya Palupi, Indriati Hapsari, |
|---|---|
| Format: | Article application/pdf eJournal |
| Bahasa: | ind |
| Terbitan: |
STIFAR - Sekolah Tinggi Ilmu Farmasi
, 2014
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| Online Access: |
http://journal.stifar.ac.id/ojs/index.php/js/article/view/61 |
Daftar Isi:
- This research aimed to know the influence of cauliflower (Brassica oleracea L. var btrytis L.) juice pretreatment on diclofenac activity in inflammation therapy to wistar white male rats. thirty rats were divided into 6 groups using randomized deisgn. Groups I (negative control) was only given akuades, while group II (positive control) was given treatment with sodium diclofenac orally as the dose as 5,04 mg/kg BW.Group III was given pretreatment of cauliflower juice with dose of 20 ml/kg BW. it was given one our before treatment with sodium diclofenac. Group IV was given pretreatment of cauliflower juice with the dose of 20 ml/kg BW and it was given one day before tratment with sodium diclofenac. Group V was given pretratment of cauliflower juice with single dose 20 ml/kg BW for 3 days before treatment with sodium diclofenac, and group VI was given pretratment of cauliflower juice with single dose 20 ml/kg BW for 5 days before treatment with sodium diclofenac. Thirty minutes after treatment with sodium diclofenac, the rat's paw was injected woth 1% carrageenan 0,10 ml subplantary. Edema volume was measured from 0th hour to 5th hour after carrageenan injection using pletismometer. The result of statistic analysis of AUC and DAI data have shown that cauliflower juice pretreatment given one hour before treatment with sodium diclofenac did not show significant different with positive control. The research showed that cauliflower juice pretreatment for 3 and 5 days was capable as reducing antiinflamation activity of diclofenac, therefore inflamation therapy with diclofenac was not maximum