KELAINAN PERKEMBANGAN KRANIOFACIAL FETUS MENCIT (Mus musculus L.) Strain DDW SETELAH PEMBERIAN EKSTRAK N-HEKSAN BUAH ANDALIMAN (Zanthoxylum acanthopodium DC.)
| Main Authors: | Sarah, Mai; Universitas Sumatera Utara, Sabri, Emita, Hutahaean, Salomo |
|---|---|
| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Saintia Biologi
, 2012
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| Online Access: |
https://jurnal.usu.ac.id/index.php/sbiologi/article/view/942 https://jurnal.usu.ac.id/index.php/sbiologi/article/view/942/496 |
Daftar Isi:
- The purpose of this study is to investigate the effect of n-hexane extract of andaliman (Zanthoxylum acanthopodium DC.) fruit on craniofacial development of DDW Mice (Mus musculus L.). Experiment was carried out using Completely Randomized Design (CRD) with 5 treatments and 6 replicates. Treatments consist of a blank control, vehicle control (1% CMC) and 3 concentrations of andaliman extract (2%, 4% and 6%). All treatments were administered by oral gavage (0.1 ml/10 g bw) once daily from day 0 to day 10 of gestation. N-hexane extract of andaliman fruit induced developmental abnormalities in craniofacial structures i.e. increased the incidence of microphthalmia (P <0.05), and hydrocephalus (P <0.05). In conclusion, we suggested that andaliman fruit may have fetotoxic effects. Keyword: andaliman (Zanthoxylum acanthopodium DC.), micropthalmia, hydrocephalus