PENGARUH PEMBERIAN VITAMIN C DAN E TERHADAP GAMBARAN HISTOLOGIS HEPAR MENCIT (Mus musculus L.) YANG DIPAJANKAN MONOSODIUM GLUTAMAT (MSG)
| Main Authors: | Maulida, Ahri; Sumatera Utara University, Ilyas, Syafruddin, Hutahaean, Salomo |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Saintia Biologi
, 2013
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| Online Access: |
https://jurnal.usu.ac.id/index.php/sbiologi/article/view/1277 https://jurnal.usu.ac.id/index.php/sbiologi/article/view/1277/663 |
Daftar Isi:
- This study aimed to determine the effects of vitamin C and E on liver microstructure of mouse exposed to monosodium glutamate (MSG) for 30 days. The experiment used completely randomized design which consists of 6 treatments and 5 replications. Mice were treated daily by oral gavage with 4 mg MSG (P1), 4 mg MSG + 0.26 mg vitamin C (P2), 4 mg MSG + 0.026 vitamin E (P3), or 4 mg MSG + 0.26 mg vitamin C + 0.026 mg vitamin E (P4). All dosages were based on mg/g body weight. Two control groups K- and K+ were treated with water and castor oil respectively. The mice liver tissue slide was prepared by the paraffin method and stained with haematoxylin-eosin (HE). The results showed that MSG caused cell degeneration and necrosis in liver tissue. Vitamin C and E was able to recover liver cell damage induced by MSG. The highest result was found in P3 and combination treatment (P4) where the recovery effect reaches 64% and 80% respectively. Keywords : Liver, Monosodium glutamate (MSG), Vitamin C, Vitamin E.