Development of an environment-friendly and solvent-free synthetic route for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones by La(NO3)3.6H2O as an efficient catalyst
| Main Author: | Farzaneh Mohamadpour; Young Researchers and Elite Club, Shiraz Branch, Islamic Azad University, Shiraz |
|---|---|
| Format: | Article application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Directorate of Research and Community Engagement, Universitas Indonesia
, 2018
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| Subjects: | |
| Online Access: |
http://journal.ui.ac.id/index.php/science/article/view/9899 |
Daftar Isi:
- Facile and environment-friendly procedure for the synthesis of corresponding 3,4-dihydropyrimidin-2-(1H)-ones/thiones derivatives were developed via one-pot three-component Biginelli reaction between β-keto esters (methyl or ethyl acetoacetate), aromatic aldehyde (benzaldehye derivatives) and urea or thiourea in the presence of Lanthanum (III) Nitrate Hexahydrate (La(NO3)3.6H2O) as highly efficient catalyst under solvent-free conditions. This protocol has advantages such as readily, inexpensive and non-toxic catalyst, simple reaction work-up catalyst, high atom-economy, excellent yields and short reaction times.