CrCl3•6H2O As an Environmentally Friendly and Efficient Catalyst for One-Pot, Synthesis of 2-oxo- and 2-thio-1,2,3,4-Tetrahydropyrimidines Under Solvent-Free Conditions
| Main Author: | Farzaneh Mohamadpour; Young Researchers and Elite Club, Shiraz Branch, Islamic Azad University, Shiraz 7184948174 |
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| Format: | Article application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Directorate of Research and Community Engagement, Universitas Indonesia
, 2018
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| Subjects: | |
| Online Access: |
http://journal.ui.ac.id/index.php/science/article/view/9865 http://journal.ui.ac.id/index.php/science/article/download/9865/67547811 |
Daftar Isi:
- A one-pot, simple, and eco-friendly synthesis of 2-oxo- and 2-thio-1,2,3,4-tetrahydropyrimidines using a Biginelli condensation between β-keto esters (methyl or ethyl acetoacetate), aromatic benzaldehydes, and urea or thiourea in the presence of CrCl3·6H2O as an environmentally friendly and mild catalyst under solvent-free conditions has been performed. Based on reaction of benzaldehyde (1.0 mmol), ethyl acetoacetate (1.0 mmol), and urea (1.5 mmol), as well as 15 mol% of CrCl3·6H2O catalyst, the 82% yield was reached within 30 minute reaction time. The advantages of this methodology are solvent-free conditions, ease of handling, one-pot nature, low-cost, environmental friendliness, simple purification of products, and short reaction time.