Antioxidant Constituents from the Bark of Aglaia eximia (Meliaceae)

Main Authors: Julinton Sianturi; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang 45363, Indonesia, Kindi Farabi; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang 45363, Indonesia, Tri Mayanti; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang 45363, Indonesia, Desi Harneti; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang 45363, Indonesia, Darwati Darwati; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang 45363, Indonesia, Unang Supratman; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang 45363, Indonesia, Khalijah Awang; Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 59100, Malaysia, Hideo Hayashi; Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Gakuen-cho, Sakai, Osaka 599-8531, Japan
Format: Article application/pdf eJournal
Bahasa: eng
Terbitan: Directorate of Research and Community Engagement, Universitas Indonesia , 2016
Subjects:
Online Access: http://journal.ui.ac.id/index.php/science/article/view/5655
Daftar Isi:
  • The genus Aglaia is a a rich source of different compounds with interesting biological activities. A part of our continuing search for novel biologically active compounds from Indonesia Aglaia plants, the ethyl acetate extract of bark of Aglaia eximia showed significant antioxidant activity. Four antioxidant compounds, kaempferol (1), kaempferol-3-O-α-L-rhamnoside (2), kaempferol-3-O-β-D-glucoside (3) and kaempferol-3-O-β-D-glucosyl-(1→4)-α-L-rhamnoside (4) were isolated from the bark of Aglaia eximia (Meliaceae). The chemical structures of compounds 1-4 were identified on the basis of spectroscopic datas including  UV, IR, NMR and MS along with by comparison with those spectra datas previously reported. All compounds showed DPPH radical-scavenging activity with IC50 values of  1.18, 6.34, 8.17, 10.63 mg/mL, respectively.