Curcuma Domestica Volatile Oil (Curcuma domestica, Val) as Anti Inflamation Agent on Gout Arthritis Patient with High Purin Diet
| Main Authors: | Lailatul Muniroh; Department of Public Health Nutrition, Faculty of Public Health, Airlangga University, Surabaya 60115, Santi Martini; Department of Epideemiology, Faculty of Public Health, Airlangga University, Surabaya 60115, Triska Susila Nindya; Department of Public Health Nutrition, Faculty of Public Health, Airlangga University, Surabaya 60115, Rondius Solfaine; Department of Anatomical Pathology, Faculty of Veterinary Medicine, Universitas Wijaya Kusuma Surabaya, Surabaya 60225 |
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| Format: | application/pdf eJournal |
| Bahasa: | ind |
| Terbitan: |
Directorate of Research and Public Services Universitas Indonesia
, 2011
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| Subjects: | |
| Online Access: |
http://journal.ui.ac.id/index.php/health/article/view/684 |
Daftar Isi:
- Increased concentrations of crystal monosodium urea at joint and soft tissue represent induced of inflammation at gout arthritis (GA). Incidence and prevalence GA disseminate wide in developed countries in Asian range from 2-15% and In Indonesia, GA prevalence was 29% and mostly found in Minahasa, Toraja, and Batak ethnics. This research was aimed to analyse application of curcuma domestica volatile oil as anti inflammation agent on gout arthritis patient who has high purin diet and to assess specific cellular mediator Tumor Necrosis Factor-α (TNF-α). The design of the study was randomized pretest-posttest control group design with single blind treatment. The GCMS test was performed to identify active component in volatile oil. The sample was the new gout arthritis patient in Haji Public Hospital Surabaya. For a week, treatment group was assigned with volatile oil with dose 25 mg/kg body weight and the control group was given indometasin 150 mg/kg body weight. Blood samples were taken before and after treatment. Volatile oil of curcuma domestica (Curcuma domestica, val) has four fraction of active component. There was decreasing in blood urea level in treatment group (p = 0.001) and control group (p = 0.007). Both in control and treatment group, there was also decreasing in TNF-α, however it was not statistically significant.