The Carrageenan Dietary Fiber Suplementation in Feed to Improving Blood Lipid Parameters of Hypercholesterolemic Mice
| Main Authors: | Hernawati Hernawati; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Pendidikan Indonesia, Bandung 40154, Wasmen Manalu; Department of Anatomy, Physiology, and Pharmacology, Faculty of Veterinary Science, Institut Pertanian Bogor, Bogor 16680, Agik Suprayogi; Department of Anatomy, Physiology, and Pharmacology, Faculty of Veterinary Science, Institut Pertanian Bogor, Bogor 16680, Dewi Apri Astuti; Department of Nutritional Sciences and Feed Technology, Faculty of Animal Sciences, Institut Pertanian Bogor, Bogor 16680 |
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| Format: | application/pdf eJournal |
| Bahasa: | ind |
| Terbitan: |
Directorate of Research and Public Services Universitas Indonesia
, 2013
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| Subjects: | |
| Online Access: |
http://journal.ui.ac.id/index.php/health/article/view/2004 |
Daftar Isi:
- Carrageenan is example of food with high content of fiber. An experiment was conducted to study the effects of carrageenan supplementations on blood lipid parameters of hypercholesterolemic male mice. The experiment were done at animal cages Departemen of Biology Education, Indonesia University of Education and Fisiology Laboratory Faculty of Veteriner Medicine, Bogor Agricultural Institute on August 2011 until March 2012. The experimental mice were assigned into a completely randomized design with 5 treatments i.e., negative control group; normocholesterolemic mice fed with a standard diet, positive control group; hypercholesterolemic mice fed with a standard diet without carrageenan supplementation, treatments group; hypercholesterolemic mice feds with supplemented with 15%, 30%, and 46% carrageenan. The nonsoluble content of dietary fiber in the experimental treatments were 6.92, 8.75, 10.48, 12.27, and 14.05%, respectively. The parameters measured were body weight, cholesterol levels of blood serum, liver and feces, triglyceride, high density lipoprotein (HDL), low density lipoprotein (LDL) and glucose levels. Supplementation of carrageenan as a source of dietary fiber increased serum HDL concentrations, and decreased body weight, serum cholesterol, triglyceride, and LDL concentrations of hypercholesterolemic male mice without a significant effect on serum glucose consentrations. Hypercholesterolemic mice fed with a supplemented with 46% carrageenan decreased body weight by 7.99%, total serum cholesterol by 18.78%, triglyceride by 17.53%, LDL by 71.33%, and increased HDL by 15.59−20.47%. Carrageenan supplementation reduce liver cholesterol levels by 38.46% and increased cholesterol excretion through feces by 57.07%. Supplementation of 46% carrageenan in hipercholesterolemic fed is effective in improving blood lipid parameters of hypercholesterolemic male mice.