Polimorfisasi dan Solvatomorfi Amoksisilina Trihidrat setelah Proses beku Kering
| Main Authors: | Nugrahani, Ilma; Fakultas Farmasi Universitas Pancasila Jakarta, Asyarie, Sukmadjaja; Sekolah Farmasi ITB Bandung, Soewandhi, Sundani Nurono; Sekolah Farmasi ITB Bandung, Ibrahim, Slamet; Sekolah Farmasi ITB Bandung |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Directorate of Research and Community Engagement, Universitas Indonesia
, 2014
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| Online Access: |
http://psr.ui.ac.id/index.php/journal/article/view/3452 http://psr.ui.ac.id/index.php/journal/article/view/3452/530 |
Daftar Isi:
- The polymorphismof amoxicillin has been identified after freeze drying process. Thefreeze dried amoxicillin have some specific physical properties different from their rawmaterial, that was proved by DSC, XRD, and polarize microscope. Exothermal curvefrom DSC thermogram changes to endothermal curve, diffractogram XRD changes todifferent profile, and the crystal shows different habit. All of data showed that freezedrying process improve amoxicillin to different crystal form which has higher meltingoxidation point and lower hydrate. The improvement of the crystal structure mightbe impact to change physical-pharmaceutical properties like dissolution, absorption,and change it antibiotic potency.Keywords: amoxicillin trihydrate, freeze drying, polymorphism.