Pengaruh Ac-Di –Sol Terhadap Karakteristik Fisik dan Laju Disolusi Orally Disintegrating Tablet Piroksikam dengan Metode Cetak Langsung
| Main Authors: | Setyawan, Dwi; Departemen Farmasetika Fakultas Farmasi Universitas Airlangga Surabaya, Widjaja, Bambang; Departemen Farmasetika Fakultas Farmasi Universitas Airlangga Surabaya, Sayekti, Indah; Departemen Farmasetika Fakultas Farmasi Universitas Airlangga Surabaya |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Directorate of Research and Community Engagement, Universitas Indonesia
, 2014
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| Online Access: |
http://psr.ui.ac.id/index.php/journal/article/view/3451 http://psr.ui.ac.id/index.php/journal/article/view/3451/529 |
Daftar Isi:
- Orally Disintegrating Tablet (ODT) or Fast Release Tablet is solid dosage form whichdisintegrated rapidly in mouth and its residue easy to swallowed. This research observedthe influence of Ac-Di-Sol concentration as disintegrant on physical characteristicsand dissolution rate of piroxicam orally disintegrating tablet which wereprepared by direct compression. Ac-Di-Sol was used in concentration of 1%, 3% and5%, and 0% as control. The powder blend was pressed into tablet by hydraulic presswith a pressure of 1 ton and diameter of 8 mm and its hardness, friability, disintegrationtime and dissolution rate were examined. The results showed that the increasingof Ac-Di-Sol concentration would increase hardness, disintegration time, dissolutionrate and decrease friability of the tablet. From statistical analysis (µ =0,05), it wasshowed that there was significant difference among formulas on the hardness, friability,disintegration time and dissolution rate. The hardness of piroxicam Orally DisintegratingTablet of all formulas were between 0.99 - 2.77 kP, friability were between3.45 – 1.35%, disintegration time were between 223.67 – 20,0 sec and drug releasedat 45 minutes were between 32.71 – 96.25%. From this research, it could be concludedthat formula with 3% concentration of Ac- Di-Sol give the most desirableoutput, even though there was a problem with the friability.Keywords : Orally disintegrating tablet, piroxicam, Ac-Di-Sol, direct compression,physical characteristics, dissolution rate.