Pengaruh Pemberian Infusa Herba Sambiloto (Andrographis paniculata Nees) Terhadap Glibenklamid Dalam Menurunkan Kadar Glukosa Darah Tikus Putih Jantan yang Dibuat Diabetes
| Main Authors: | Sari, Santi Purna; Fakultas Farmasi, Universitas Indonesia, Azizahwati, Azizahwati; Fakultas Farmasi, Universitas Indonesia, Ratimanjari, Diandra Andina; Fakultas Farmasi, Universitas Indonesia |
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| Format: | Article info application/force-download eJournal |
| Bahasa: | eng |
| Terbitan: |
Directorate of Research and Community Engagement, Universitas Indonesia
, 2014
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| Subjects: | |
| Online Access: |
http://psr.ui.ac.id/index.php/journal/article/view/3359 http://psr.ui.ac.id/index.php/journal/article/view/3359/437 |
| ctrlnum |
article-3359 |
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title lang="en-US">Pengaruh Pemberian Infusa Herba Sambiloto (Andrographis paniculata Nees) Terhadap Glibenklamid Dalam Menurunkan Kadar Glukosa Darah Tikus Putih Jantan yang Dibuat Diabetes</title><creator>Sari, Santi Purna; Fakultas Farmasi, Universitas Indonesia</creator><creator>Azizahwati, Azizahwati; Fakultas Farmasi, Universitas Indonesia</creator><creator>Ratimanjari, Diandra Andina; Fakultas Farmasi, Universitas Indonesia</creator><subject lang="en-US">alloxan; Andrographis paniculata Nees; creat herb infusion; diabetes mellitus; glibenclamide</subject><description lang="en-US">Many diabetics perform self-medication with antidiabetic herbs and synthetic drugs with the aim to obtain a synergistic or additive effects without informing their primary physician, such as the use of creat and glibenclamide. This research was carried out to know the  impact of creat herb infusion on glibenclamide in bwering blood glucose levels on diabetic male albino rats. This study used 24 male Sparague-Lawley rats, which are divided into 6 groups, normal control and diabetic control were given 0,5% CMC solution I ml/200 g bw  of rat, glibenclamide control were given glibenclamide suspension 0,9 mg/200 g bw of rat, creat control were given creat herb infusion 50 mg/200 g bw of rat, and 2 interaction groups were given creat herb infusion in 2 variant doses (50 and 100 mg/ 200 g bw of rat) and glibenclamide suspension 0,9 mg/200 g bw of rat, each of them were administrated orally. All of groups were induced with alloxan 32 mg/ 200 g bw of rat except normal control. Blood glucose was measured by 0-toluidine method at 2 hours and 4 hours after administration. The result showed that the creat herb infusion at 100 mg/200 g bw gave significant impact on glibenclamide in lowering blood glucose levels week after administration. Keywords: alloxan, Andrographis paniculata Nees, creat herb infusion, diabetes mellitus, glibenclamide</description><publisher lang="en-US">Directorate of Research and Community Engagement, Universitas Indonesia</publisher><date>2014-10-02</date><type>Journal:Article</type><type>Other:info:eu-repo/semantics/publishedVersion</type><type>Other:</type><type>File:application/force-download</type><identifier>http://psr.ui.ac.id/index.php/journal/article/view/3359</identifier><identifier>10.7454/psr.v9i1.3359</identifier><source lang="en-US">Pharmaceutical Sciences and Research (PSR); Vol 9, No 1 (2012); 1-11</source><source>2477-0612</source><source>2407-2354</source><language>eng</language><relation>http://psr.ui.ac.id/index.php/journal/article/view/3359/437</relation><rights lang="en-US">Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).</rights><recordID>article-3359</recordID></dc>
|
| language |
eng |
| format |
Journal:Article Journal Other:info:eu-repo/semantics/publishedVersion Other Other: File:application/force-download File Journal:eJournal |
| author |
Sari, Santi Purna; Fakultas Farmasi, Universitas Indonesia Azizahwati, Azizahwati; Fakultas Farmasi, Universitas Indonesia Ratimanjari, Diandra Andina; Fakultas Farmasi, Universitas Indonesia |
| title |
Pengaruh Pemberian Infusa Herba Sambiloto (Andrographis paniculata Nees) Terhadap Glibenklamid Dalam Menurunkan Kadar Glukosa Darah Tikus Putih Jantan yang Dibuat Diabetes |
| publisher |
Directorate of Research and Community Engagement, Universitas Indonesia |
| publishDate |
2014 |
| topic |
alloxan Andrographis paniculata Nees creat herb infusion diabetes mellitus glibenclamide |
| url |
http://psr.ui.ac.id/index.php/journal/article/view/3359 http://psr.ui.ac.id/index.php/journal/article/view/3359/437 |
| contents |
Many diabetics perform self-medication with antidiabetic herbs and synthetic drugs with the aim to obtain a synergistic or additive effects without informing their primary physician, such as the use of creat and glibenclamide. This research was carried out to know the impact of creat herb infusion on glibenclamide in bwering blood glucose levels on diabetic male albino rats. This study used 24 male Sparague-Lawley rats, which are divided into 6 groups, normal control and diabetic control were given 0,5% CMC solution I ml/200 g bw of rat, glibenclamide control were given glibenclamide suspension 0,9 mg/200 g bw of rat, creat control were given creat herb infusion 50 mg/200 g bw of rat, and 2 interaction groups were given creat herb infusion in 2 variant doses (50 and 100 mg/ 200 g bw of rat) and glibenclamide suspension 0,9 mg/200 g bw of rat, each of them were administrated orally. All of groups were induced with alloxan 32 mg/ 200 g bw of rat except normal control. Blood glucose was measured by 0-toluidine method at 2 hours and 4 hours after administration. The result showed that the creat herb infusion at 100 mg/200 g bw gave significant impact on glibenclamide in lowering blood glucose levels week after administration. Keywords: alloxan, Andrographis paniculata Nees, creat herb infusion, diabetes mellitus, glibenclamide |
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Universitas Indonesia |
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Perpustakaan Universitas Indonesia |
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