Uji Aktivitas Antibakteri 1-[(Kuinazolin-4-on-2-il)metil]piridin-1-ium Bromida dan 2-Bromometilkuinazolin-4-on
| Main Authors: | Hayun, Hayun, Arrahman, Arif, Suryadi, Herman, Yanuar, Arry |
|---|---|
| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Directorate of Research and Community Engagement, Universitas Indonesia
, 2014
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| Subjects: | |
| Online Access: |
http://psr.ui.ac.id/index.php/journal/article/view/3303 http://psr.ui.ac.id/index.php/journal/article/view/3303/572 http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/3303/498 http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/3303/499 http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/3303/500 http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/3303/501 http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/3303/502 |
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title lang="en-US">Uji Aktivitas Antibakteri 1-[(Kuinazolin-4-on-2-il)metil]piridin-1-ium Bromida dan 2-Bromometilkuinazolin-4-on</title><creator>Hayun, Hayun</creator><creator>Arrahman, Arif</creator><creator>Suryadi, Herman</creator><creator>Yanuar, Arry</creator><subject lang="en-US">quinazolinone-pyridinium; bromomethyl quinazolinone; antibacterial; kuinazolinon-piridium; bromometil kuinazolinon; antibakteri</subject><description lang="en-US">Antibacterial activity tests of quinazolin-4-one derivates: 1-[(6-nitroquinazolin-4-one- 2-yl)methyl]piridin-1-ium bromide (1), 1-[(6-aminoquinazolin-4-on-2-yl)methyl]piridin-1-um bromide (2), 2-bromomethylquinazolin-4-one (3) and 2-bromomethyl-6-nitroquinazolin-4-one (4) with trimethoprim (5) as a positive standard were conducted. The antibacterial activity tests were carried out using disc diffusion method againts E. coli, S. aureus and S. thyposa, and determination of minimum inhibitory concentration (MIC). The results showed that compounds 1 and 2 are inactive as antibacterial, whereas compounds 3 and 4 are active. The activities to E. coli were 1&frasl;4 times the activity of trimethoprim (MIC : 5 x 10 2 &mu;g/ml compared to 1.25 x10 2 &mu;g/ml ). The activity to S. typhosa were 1&frasl;2-1 times the activity of trimethoprim (MIC: 2.5 and 1.25x10 2 &mu;g/ml compared to 1.25x10 2 &mu;g/ml); but they are not active to S. aureus. Trimethoprim active to S. aureus with MIC : 0.62 x10 2 &mu;g/ ml.</description><publisher lang="en-US">Directorate of Research and Community Engagement, Universitas Indonesia</publisher><date>2014-04-03</date><type>Journal:Article</type><type>Other:info:eu-repo/semantics/publishedVersion</type><type>Other:</type><type>File:application/pdf</type><identifier>http://psr.ui.ac.id/index.php/journal/article/view/3303</identifier><identifier>10.7454/psr.v1i1.3303</identifier><source lang="en-US">Pharmaceutical Sciences and Research (PSR); Vol 1, No 1 (2014); 1-8</source><source>2477-0612</source><source>2407-2354</source><language>eng</language><relation>http://psr.ui.ac.id/index.php/journal/article/view/3303/572</relation><relation>http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/3303/498</relation><relation>http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/3303/499</relation><relation>http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/3303/500</relation><relation>http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/3303/501</relation><relation>http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/3303/502</relation><rights lang="en-US">Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).</rights><recordID>article-3303</recordID></dc>
|
| language |
eng |
| format |
Journal:Article Journal Other:info:eu-repo/semantics/publishedVersion Other Other: File:application/pdf File Journal:eJournal |
| author |
Hayun, Hayun Arrahman, Arif Suryadi, Herman Yanuar, Arry |
| title |
Uji Aktivitas Antibakteri 1-[(Kuinazolin-4-on-2-il)metil]piridin-1-ium Bromida dan 2-Bromometilkuinazolin-4-on |
| publisher |
Directorate of Research and Community Engagement, Universitas Indonesia |
| publishDate |
2014 |
| topic |
quinazolinone-pyridinium bromomethyl quinazolinone antibacterial kuinazolinon-piridium bromometil kuinazolinon antibakteri |
| url |
http://psr.ui.ac.id/index.php/journal/article/view/3303 http://psr.ui.ac.id/index.php/journal/article/view/3303/572 http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/3303/498 http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/3303/499 http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/3303/500 http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/3303/501 http://psr.ui.ac.id/index.php/journal/article/downloadSuppFile/3303/502 |
| contents |
Antibacterial activity tests of quinazolin-4-one derivates: 1-[(6-nitroquinazolin-4-one- 2-yl)methyl]piridin-1-ium bromide (1), 1-[(6-aminoquinazolin-4-on-2-yl)methyl]piridin-1-um bromide (2), 2-bromomethylquinazolin-4-one (3) and 2-bromomethyl-6-nitroquinazolin-4-one (4) with trimethoprim (5) as a positive standard were conducted. The antibacterial activity tests were carried out using disc diffusion method againts E. coli, S. aureus and S. thyposa, and determination of minimum inhibitory concentration (MIC). The results showed that compounds 1 and 2 are inactive as antibacterial, whereas compounds 3 and 4 are active. The activities to E. coli were 1⁄4 times the activity of trimethoprim (MIC : 5 x 10 2 μg/ml compared to 1.25 x10 2 μg/ml ). The activity to S. typhosa were 1⁄2-1 times the activity of trimethoprim (MIC: 2.5 and 1.25x10 2 μg/ml compared to 1.25x10 2 μg/ml); but they are not active to S. aureus. Trimethoprim active to S. aureus with MIC : 0.62 x10 2 μg/ ml. |
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