Aktivitas Imunomodulator Ekstrak Buah Mengkudu pada Mencit yang Diinfeksi Staphylococcus aureus (IMMUNOMODULATORS ACTIVITY OF NONI (MORINDA CITRIFOLIA L.) FRUIT EXTRACT IN MICE INFECTED WITH STAPHYLOCOCCUS AUREUS)
| Main Authors: | Mufidah, Zumrotul; Bagian Klinik Hewan, Fakultas Kedokteran Hewan, Universitas Udayana, Bali, Rifa’i, Muhaimin, Rahayu, Sri |
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| Format: | Article application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Jurnal Veteriner
, 2013
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| Subjects: | |
| Online Access: |
http://ojs.unud.ac.id/index.php/jvet/article/view/7686 |
Daftar Isi:
- This study aim was to determine the immunomodulatory activity of noni (Morinda citrifolia L.) fruitextract in mice infected with Staphylococcus aureus. Mice were divided into two group : non-infected andinfected. Non Infected group was without S. aureus infection whereas the infected group was infected withS. aureus. Group contain control, dose 1 (25 mg/kg BW), dose 2 (100 mg/kg BW), and dose 3 (300 mg/kg BW).Oral treatment carried out for 20 days in every morning and each sample was injected with S. aureus atday 21 with 109 cell/mL. Relative number of T cell (CD4+, CD4+CD25+),) and cytokine interferon-ã fromCD4+ T cell (CD4+IFN-ã+) subsets was measured using the BD FACSCaliburTM Flowcytometer. Data wereanalyzed by using Analysis of Varians (p<0,05) and SPSS 16 for windows. The result showed thatadministration of noni crude extract was significantly change the relative number of CD4+, CD4+IFN-ã+,and CD4+CD25+ T cells. Treatment of noni crude extract in non-infection group could increase relativenumber of CD4+, CD4+IFN-ã+ and CD4+CD25+ T cells that might be caused by active compounds of noni asmitogen. Giving of noni crude extract in infected group could reduce the relative number of CD4+, CD4+CD25+and CD4+IFN-ã+ T cells due to it active compounds as anti-inflamation. Noni fruit extract can be used aspreventive therapy on S. aureus infection because it contains active compounds as an anti-inflammationeffect.