DENTIN REPARATIF DAN GROWTH FACTOR YANG BERPERAN DALAM DENTINOGENESIS REPARATIF (REPARATIVE DENTIN AND THE ROLE OF GROWTH FACTOR IN REPARATIVE DENTINOGENESIS)
| Main Author: | Octiara, Essie |
|---|---|
| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Fakultas Kedokteran Gigi USU
, 2017
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| Online Access: |
https://jurnal.usu.ac.id/index.php/dentika/article/view/18230 https://jurnal.usu.ac.id/index.php/dentika/article/view/18230/7745 https://jurnal.usu.ac.id/index.php/dentika/article/downloadSuppFile/18230/3408 |
Daftar Isi:
- AbstractReparative dentin is defined as a tertiary dentin matrix secreted by a new generation of odontoblast-like cell in response to an appropriate stimulus after the death of the original postmitotic odontoblast. Reparative dentinogenesis involves progenitor cell from the pulp, must be recruited and induced to differentiate into odontoblast-like cell before its secretion may be upregulated to form the reparative dentin matrix. One of which plays a role in the reparative dentinogenesis is growth factors, which act as a regulatory cell functions such as proliferation, differentiation and matrix synthesis. Different types of growth factors that play a role in the regeneration of complex pulp include Transforming Growth Factor-β (TGFS-β ), Bone Morphogenetic Protein ( BMPs ), Platelet Derived Growth Factor ( PDGF ), Insuline Like Growth Factor ( IGF ) and fibroblast growth factor ( FGFs ).Key words: reparative dentin, odontoblast-like cell, growth factorAbstrak Dentin reparatif adalah matriks dentin tersier yang disekresikan oleh sel odontoblast-like cell baru, untuk merespons stimulus yang kuat setelah terjadinya kematian odontoblast postmitotic. Dentinogenesis reparatif melibatkan sel progenitor dan adanya induksi diferensiasi dari odontoblast-like cell sebelum terjadinya sekresi matrix dentin reparatif. Salah satu yang berperan dalam dentinogenesis reparatif adalah growth factor, yang bertindak sebagai regulasi beberapa fungsi sel seperti proliferasi, diferensiasi dan sintesis matriks. Berbagai jenis growth factor yang berperan dalam regenerasi kompleks pulpa antara lain, Transforming Growth Factor-β (TGFS-β), Bone Morphogenetic Protein (BMPs), Platelet Derived Growth Factor (PDGF), Insuline Like Growth Factor (IGF) dan Fibroblast Growth Factor (FGFs). Kata kunci: dentin reparatif, odontoblast like cell, growth factor