Perbedaan Kadar SGOT antara Pemberian Air Rebusan Daun Sendok (Plantago major) dan Daun Sambiloto (Andrographis paniculata Ness) Studi Eksperimen pada Tikus Putih Jantan Galur Wistar yang Diinduksi Parasetamol The Difference in SGOT Level between Boiled A
| Main Authors: | Goenarwo, Edijanti; Bagian Farmakologi Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA), -, Chodidjah -; Bagian Anatomi FK Unissula Semarang, Kusuma, Rosy -; Mahasiswa FK Unissula |
|---|---|
| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Fakultas Kedokteran, Universitas Islam Sultan Agung (UNISSULA)
, 2012
|
| Subjects: | |
| Online Access: |
http://sainsmedika.fkunissula.ac.id/index.php/sainsmedika/article/view/30 http://sainsmedika.fkunissula.ac.id/index.php/sainsmedika/article/view/30/16 |
Daftar Isi:
- ABSTRACTBackground: Paracetamol has been shown to cause liver damage indicated by the increase of SGOT level.The leave of sendok (Plantago major) and sambiloto (Andrographis paniculata Ness) have been shown tohave a hepatoprotective activity used to repair liver damage. The efficacy of the two leaves has not beenestablished. This study aims at finding out the difference of SGOT level in rats treated with the boiled aquoussendok and sambiloto leave in male wistar rats.Design and Method: This experimental study used post test randomized control group design. The malewistar rats were divided into four groups randomly, Group I were administered with aquadest for 16 days,Group II were treated with single dose of Paracetamol 1 mg/gram bw/day followed by aquadestadministration on days 3 to 16, Group III and IV were treated by paracetamol prior to boiled aquous ofsendok and sambiloto leave as 2.7 ml/day.Result: The mean of SGOT level for the four group were 78.87, 87.22, 84.21, dan 81.57 IU/L, respectively. OneWay Anova shows a significant differente SGOT level among the groups (p<0.000).Conclusion: The boiled aquous of sendok and sambiloto leave might have an effect to decrease the SGOTlevel. The boiled aquous of sendok and sambiloto leave might decrease the SGOT level of the paracetamolinduced rats during the 16 day, but the decreasein of SGOT level on boiled aquous of sambiloto leave treatmentwas higher than in sendok group (Sains Medika, 2(1):41-45).Key words: hepatoprotector, hepatoregenerasi, paracetamol, SGOTABSTRAKPendahuluan: Parasetamol diketahui dapat menyebabkan kerusakan sel hati yang ditandai denganmeningkatnya kadar SGOT. Daun sendok dan daun sambiloto diketahui dapat memperbaiki kerusakansel hati, akan tetapi belum diketahui perbedaan efektifitasnya. Oleh karena itu, perlu diteliti perbedaankadar SGOT antara pemberian air rebusan daun sendok dan daun sambiloto.Metode Penelitian: Penelitian ini bersifat eksperimental, dengan rancangan post test randomized controlgroup design menggunakan tikus putih jantan galur wistar. Hewan uji dibagi menjadi 4 kelompokperlakuan: K-I kontrol diberi aquades selama 16 hari, K-II diberi Parasetamol 1 mg/gram BB dosis tunggalkemudian hari ke-3 sampai ke-16 diberi aquades, K-III dan K-IV, masing-masing diinduksi parasetamolsama dengan kelompok II kemudian diberi air rebusan daun sendok dan daun sambiloto 2,7 ml/hari.Hasil Penelitian: Rerata kadar SGOT pada K-I, K-II, K-III, dam K-IV secara berurutan sebesar 78,87; 87,22;84,21; dan 81,57 IU/L. Hasil uji One Way Anova menunjukkan terdapat perbedaan kadar SGOT antarmasing-masing kelompok (p< 0,000).Kesimpulan: Air rebusan daun sendok dan daun sambiloto mempunyai efek menurunkan kadar enzimSGOT tikus putih jantan yang diinduksi parasetamol selama perlakuan 16 hari, akan tetapi penurunankadar enzim SGOT lebih besar pada perlakuan daun sambiloto (Sains Medika,2(1):41-45).Kata kunci: hepatoprotektor, hepatoregenerasi, parasetamol, SGOT