Kualitas Hidup Penderita Rinitis Alergi setelah Pemberian Kombinasi Probiotik Quality of Life Allergic Rhinitis after Probiotic Combination Supplementation
| Main Authors: | Wardani, Andriana Tjitria Widi, Soetoko, Anita Soraya |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Fakultas Kedokteran, Universitas Islam Sultan Agung (UNISSULA)
, 2013
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| Subjects: | |
| Online Access: |
http://sainsmedika.fkunissula.ac.id/index.php/sainsmedika/article/view/143 http://sainsmedika.fkunissula.ac.id/index.php/sainsmedika/article/view/143/113 |
Daftar Isi:
- Background: Probiotics are potential as a therapy for allergy sufferers, which can increase the ratio IFN?, IL4.However, the effects of probiotics on the quality of life of patients with allergic rhinitis have not been developedyet. This study aimed to determine the effect of a combination of probiotics on the quality of life of patients withallergic rhinitis.Design and Methods: This study used a randomized design with post test control group design. The populationsin this study were men and women aged 18-25 years who suffer from allergic rhinitis with moderate to severeaccording to the WHO criteria. This study uses two groups: the group treated by administration of a combinationof probiotics and the control group were given a placebo. Quality of life was assessed by checklist scores andlevels of IgE. Data were analyzed using the Mann Whitney U test with 95% confidence intervals.Results: The results of statistical analysis showed no significant difference between the quality of life of allergicrhinitis sufferers control and treatment groups (p> 0.05). However, there are significant differences between themean levels of IgE allergy sufferers rhintis control and treatment groups (p <0.05).Conclusion: Probiotic treatment did not affect the quality of life of patients with allergic hinitis but a reduction inthe levels of IgE (Sains Medika, 4(2):157-164).Latar Belakang: Probiotik berpotensi sebagai terapi bagi penderita alergi, diantaranya dapat meningkatkan rasioIFN?, IL4. Namun, sejauh ini masih belum diketahui pengaruh probiotik terhadap kualitas hidup penderita rinitisalergi. Penelitian ini bertujuan untuk mengetahui efek pemberian kombinasi probiotik terhadap kualitas hiduppenderita rinitis alergi.Metode: Penelitian ini menggunakan rancangan randomized post test with control group design. Populasi dalampenelitian ini adalah pria dan wanita usia 18-25 tahun yang menderita rinitis alergi dengan derajat sedang sampaiberat sesuai dengan kriteria WHO. Penelitian ini menggunakan 2 kelompok yaitu kelompok perlakukan denganpemberian kombinasi probiotik dan kelompok kontrol yang diberikan plasebo. Kualitas hidup dinilai berdasarkanskor checklist dan kadar IgE. Data yang diperoleh dianalisis dengan menggunakan uji Mann Whitney U denganinterval kepercayaan 95%.Hasil: Hasil analisa statistik menunjukkan tidak terdapat perbedaan signifikan antara kualitas hidup penderitarinitis alergi kelompok kontrol dan perlakuan (p>0,05). Namun, terdapat perbedaan signifikan antara rerata kadarIgE penderita rhintis alergi kelompok kontrol dan perlakuan (p<0,05).Kesimpulan: Pemberian probiotik tidak berpengaruh terhadap kualitas hidup penderita rinitis namun berpengaruhterhadap penurunan kadar IgE (Sains Medika, 4(2):157-164).