Formulasi Tablet Salut Selaput Katekin dari Ekstrak Gambir (Uncaria gambir Roxb.)
| Main Authors: | Kurniatri, Arifayu Addiena; Pusat Biomedis dan Teknologi Dasar Kesehatan, Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan, Adelina, Rosa; Pusat Biomedis dan Teknologi Dasar Kesehatan, Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan, Setyorini, Herni Asih; Pusat Biomedis dan Teknologi Dasar Kesehatan, Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan, Sulistyowati, Indah; Pusat Biomedis dan Teknologi Dasar Kesehatan, Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan |
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| Format: | Article application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Center for Biomedical and Basic Technology of Health,National Institute of Health Research
, 2015
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| Subjects: | |
| Online Access: |
http://ejournal.litbang.depkes.go.id/index.php/jki/article/view/4402 |
Daftar Isi:
- Gambir extract contains a high content of catechin. Catechin has so many benefits, such as antioxidant, antimicrobial, and anti-atherosclerosis.Gambir are widely available in Indonesia, especially in West Sumatra, might be a sustainable source of catechin. Catechin is easily oxidized and hygroscopic. Film coating is used to protect catechin contained in a tablet from moisture and light. Study of film-coated tablet of catechin has not been conducted before. This study aims to formulate film-coated tablet of catechin from gambir and evaluate its physical properties. Catechin was percolated from gambir extract using ethyl astetat. The ethyl acetate fraction of gambir extract contains 92,48±0,28% catechin. Tablets were compressed with direct compression method and coated with a polymer coating material. The physical properties of core tablet and film-coated tablet were evaluated toward weight uniformity, hardness, friability, and disintegration time. Friability testing was conducted only on core tablet. The formulation produced tablets with uniform weight, 16,6 ±1,97 Kp hardness, and 4 minutes 15 seconds disintegration time. Weight uniformity and disintegration time of the tablet meet the requirements