Karakterisasi Kompleks Inklusi Asam Mefenamat - β -Siklodekstrin yang Dibuat dengan Metode Freeze Drying
| Main Authors: | Setyawan, Dwi; Departemen Farmasetika Fakultas Farmasi Universitas Airlangga, Isadiartuti, Dewi; Departemen Farmasetika Fakultas Farmasi Universitas Airlangga |
|---|---|
| Other Authors: | BADAN LITBANGKES KEMENKES |
| Format: | Article application/pdf eJournal |
| Bahasa: | ind |
| Terbitan: |
Center for Biomedical and Basic Technology of Health,National Institute of Health Research
, 2012
|
| Online Access: |
http://ejournal.litbang.depkes.go.id/index.php/jki/article/view/1290 |
Daftar Isi:
- Characterization of mefenamic acid-β-cyclodextrin inclusion complexes by freeze drying method had been studied. Solid state mefenamic acid- β-cyclodextrin inclusion complex prepared by freeze drying method in 1:1 molar ratio. Mefenamic acid, β-cyclodextrin, mefenamic acid-β-cyclodextrin physical mixture and inclusion complexes were characterized by Powder X-ray Diffraction (PXRD), Fourier Transform Infrared Spectroscopy (FTIR) , Differential Thermal Analyzer (DTA) and dissolution studies. The results showed the formation of inclusion complex between mefenamic acid and β-cyclodextrin. In vitro dissolution rate studies of mefenamic acid, mefenamic acid-β-cyclodextrin physical mixture and inclusion complex were conducted using basket method and water as dissolution medium. Mefenamic acid-β-cyclodextrin inclusion complex showed increasing dissolution rate compared to mefenamic acid-β-cyclodextrin physical mixture and mefenamic acid. Key words: mefenamic acid, β-cyclodextrin, freeze drying, inclusion complex, dissolution rate