Pengaruh pemberian kurkumin dan vitamin E terhadap aktivitas angiogenesis plasenta preeklampsia = The effect of curcumin and vitamin E supplementation on angiogenesis activity in preeclamptic placenta
| Main Authors: | Candra Wijaya, author, Add author: Sri Bekti Subakir, supervisor, Add author: Oentoeng Soeradi, supervisor |
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| Format: | Masters Bachelors |
| Terbitan: |
Fakultas Kedokteran Universitas Indonesia
, 2006
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| Subjects: | |
| Online Access: |
http://lontar.ui.ac.id/detail?id=98508 |
Daftar Isi:
- Tujuan: Membandingkan aktivitas angiogenik plasenta preeklampsia dengan dan tanpa pemberian kurkumin dan vitamin E. Rancangan Penelitian: Penelitian ini merupakan studi eksperimental in vitro. Plasenta dari ibu hamil preeklampsia (n=11) dibagi dalam 3 kelompok: kelompok kontrol, kelompok pemberian kurkumin dosis 0,01 mM, dan kelompok pemberian vitamin E dosis 20 mg/L Aktivitas angiogenesis ditentukan dengan menilai skor migrasi sel-sel endotel menuju plasenta. Analisis perbedaan aktivitas angiogenesis antar kelompok digunakan tes wilcoxon. Hasil: Aktivitas angiogenik kelompok pemberian kurkumin dosis 0,01 mM tidak berbeda bermakna dibandingkan kelompok kontrol (p>0,05). Sedangkan, aktivitas angiogenik kelompok pemberian vitamin E dosis 20 mg/L berbeda secara bermakna dibandingkan kelompok kontrol (p< 0,05). Kesimpulan: Pemberian vitamin E meningkatkan aktivitas angiogenik pada plasenta dari ibu hamil preeklampsia. <hr> Objective: To compare angiogenic activity in preeclamptic placenta with and without supplementation of curcumin and vitamin E. Study design: The study was an in vitro experimental study. Placentae were obtained from woman with preeclampsia (n=11) divided into three groups. The first was control, to the second group 0,01 mM curcumin was added and the third with 20 mg/I, vitamin E. Angiogenic activity was assayed using an endothelial cell migration assay. Differences in placental angiogenic activity between three groups were analysed using the Wilcoxon test. Results: The angiogenic activity in the 0,01 mM curcumin supplementation group was not significantly different than in the control group (p>0,05). While, angiogenic activity in the 20 mg/I, vitamin E group was significantly different than in the control group (p< 0,05). Conclusion: Vitamin E supplementation increased angiogenic activity in the placenta from women with preeclampsia.