Analisis kadar matrix metalloproteinase-8 (MMP-8) pada cairan krevikular gingiva penderita periodontitis kronis dan periodontitis agresif = Analysis of matrix metalloproteinase-8 (MMP-8) in the gingival crevicular fluid of chronic and aggressive periodontitis patients / Astri Sulandari Arymami
| Main Author: | Astri Sulandari Arymami, author |
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| Format: | Masters Bachelors |
| Terbitan: |
, 2013
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| Subjects: | |
| Online Access: |
http://lib.ui.ac.id/file?file=digital/20365289-T-Pdf Astri Sulandari Arymami.pdf |
Daftar Isi:
- <b>ABSTRAK</b><br> Latar belakang: Suatu biomarker imunologis diperlukan untuk kasus yang berbatasan antara periodontitis kronis dan periodontitis agresif. Matrix Metalloproteinase-8 (MMP-8) merupakan suatu biomarker penentu risiko dan derajat keparahan penyakit periodonal serta evaluasi hasil perawatan periodontal. Tujuan: Menganalisis kadar MMP-8 pada cairan krevikular gingiva penderita periodontitis kronis dan periodontitis agresif. Metode: Penelitian ini mencakup 12 pasien periodontitis agresif, 17 pasien periodontitis kronis dan 6 subjek sehat. Kadar MMP-8 diukur dengan teknik ELISA.Hasil: Kadar MMP-8 pada periodonitits kronis tidak berbeda bermakna dengan periodontitis agresif (p>0,05). Kesimpulan:MMP-8 tidak dapat digunakan sebagai acuan diagnosis. <hr> <b>ABSTRACT</b><br> Background: An immunologic biomarker is needed to distinguish between borderline cases between chronic periodontitis and agressive periodontitis. Matrix Metalloproteinase-8 (MMP-8) can be a risk profile of periodontal disease, disease progression and evaluation of periodontal treatment. Aim: Analyze MMP-8 levels in gingival crevicular fluid of chronic and aggressive periodontitis patients. Method: Sampel was collected from 6 healthy subjects, 12 subjects aggressive periodontitis and 17 chronic periodontitis subjects. MMP-8 levels were measured with ELISA. Result:MMP-8 levels in chronic periodontitis did not show any difference to the MMP-8levels in aggressive periodonitits (p>0,05). Conclusion:MMP-8 can not serve as a diagnostic parameter.