Pengaruh suplementasi vitamin C dan E terhadap kadar GSH plasma pada kasus luka bakar sedang berat = The effect of vitamin c and e supplementation on level of plasma GSH of moderate and severe burn
| Main Authors: | Marya Warascesaria Haryono, author, Add author: Lanny Lestiani Sumali, supervisor, Add author: Yefta Moenadjat, supervisor, Add author: Ninik Mudjihartini, examiner, Add author: Dhanasari Vidiawati Trisna, examiner, Add author: Agnes Riyanti Inge Permadhi, examiner, Add author: Rudyanto Sedono, examiner |
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| Format: | Masters Bachelors |
| Terbitan: |
, 2009
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| Subjects: | |
| Online Access: |
https://lib.ui.ac.id/detail?id=20341513 |
Daftar Isi:
- <b>ABSTRAK</b><br> Tujuan penelitian ini adalah menilai kadar GSH plasma setelah suplementasi vitamin C 1000 mg intravena dan 400 mg vitamin E secara oral selama empat hari berturut-turut pada luka bakar sedang berat. Penelitian eksperimen ini dengan satu kelompok pre-post test dengan usia 18-59% tahun pada kasus luka bakar sedang berat kurang dari 60%. Dari 16 kasus yang memenuhi kriteria, diperoleh 12 kasus sehagai subjek penelitian sesuai dengan sampel yang diharapkan. Penyebab luka bakar terbanyak adalah api (75%) dan sebagian besar subyek menriliki BMI nonnal (67%) dengan rata-rata 22,04 ± 1,89 kglm2 ? Kadar vitamin C sebelurn suplementasi adalah 17,79(10,16-32,88)p.mol/L dan sesudah suplementasi adalah 18,33(9,10-37,02) p.mol/ L (p = 0,239), Nilai rata-rata serum kadar vitamin E meningkat signifikan, yaitu 9,06 ± 1,56 p.mol I L sebelurn suplementasi dan 15,50 (6,28-27,17) p.mol/L setelah suplementasi (p = 0,019). Nilai rata-rata dan kisaran kadar GSH plasma sebelum suplementasi adalah 0,54±0,11 Jlll I mL, Nilai rata-rata tingkat GSH setelah suplemen adalah l ,07 (0,94-1,68) g /mL.lni menunjukkan bahwa suplementasi vitamin C dan vitamin E bisa meningkatkan kadar GSH secara signifikan (p = 0,002). Terdapat perbedaan yang signifikan pada perubahan kadar vitamin C, vitamin E, dan GSH sebelum dan sesudah perlakuan antara luka bakar sedang dan luka bakar berat. <hr> <b>Abstract</b><br> The aimed of the study is to assess the levels of GSH after supplementation of vitamin C 1000 mg iv and 400 mg vitamin E orally for four consecutive days on a moderate to severe bums. This experimental studies with one group pre-post test involved 18-590/o years aged patients with moderate to severe burns less than 60%, From 16 cases required the criteria, there were 12 cases as the subject of research in accordance with the expected sample. The most causes of burns is fire (75%) and most of subjects have a nominal BMl (67%) with average 22.04 ± 1.89 kg /m2 ? Median value of vitamin C levels before supplementation was 17.79(10.16-32.88) and after supplementation was 18.33(9.10-37.02) ~mol/L (lr= 0.239). Average value of serum vitantin E levels increased significantly, which are 9.06 ± 1.56 mol/L befure supplementation and 15.50(6.28-27.17) mol/L after supplementation (p= 0.019). Median value and range of plasma GSH levels before supplementation was 0.54±0.11 ;tg/mL. Median value of GSH levels after supplementation was 1.07 (0.94-1.68) flgimL. This is show that the supplementation of vitamin C and vitamin E may increased GSH levels significantly (p = 0.002). There were no significant differences in changes in levels of vitamin C, vitamin E, and GSH before and after treatment among the study subjects with moderate and severe burns.