Ekspresi Ki-67 sebagai pctanda proliferasi pada karsinoma sel basal tipe agresif dan non agresif = Expression of Ki-67 as a proliverative marker in aggressive basal cell carcinoma and non-aggressive
| Main Authors: | Rosakawati, author, Add author: Aida S.D. Suriadiredja, supervisor, Add author: Sinuraya, Evlina Suzanna, supervisor, Add author: Siti Boedina Kresno, examiner, Add author: Budiana Tanurahardja, examiner, Add author: Jeanne Adiwinata Pawitan, examiner |
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| Format: | Masters Bachelors |
| Terbitan: |
, 2010
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| Subjects: | |
| Online Access: |
https://lib.ui.ac.id/detail?id=20340288 |
Daftar Isi:
- [<b>ABSTRAK</b><br> Tujuan Pemeriksaan: Membuktikan bahwa KSB tipe agresif menunjukkan ekspresi Ki-67 lebih tinggi dibandingkan dengan yang non-agresifi Material dan Metode: Pada penelitian ini didapatkan sampel sebanyak 46 blok parafin jaringan KSB tipe agresif dan non-agresif di Insta1asi Patologi Anatomi RS Kanker ?Dharmais? yang memenuhi kritcria inklusi mulai tahun 1995 - 2008 serta dapat dilacak rekam mcdiknya untuk dapat diperiksakan ekspresi Ki-67 secara imunohistokimiau Analisa data karakteristik pasien dari sampel tersebut dilakukan secara bivariat berdasarkan kelompok umur, jenis kelamin, jenis histopatologi Hasilz Rerata umur 61.30 i 11,97 tahun dengan median 61.50 tahun, pasien termuda berumur 24 tahun dan tertua 84 tahun. Berdasarkan kelompok umur didapatkan hasil sebanyak 16 pasien ( 34,8%) berumur kurang dari 60 tahun dan 30 pasien ( 65,2%) bcmmur lebih atau sama dengan 60 tahun. Pembagian berdasarkan jenis kelamin dari 46 pasiqn, laki-laki berjumlah 14 (30,4%) dan perempuan 32 (69,6%)Ekspresi Ki-67 positif pada KSB sebanyak 29 (63%) dari 46 pasien dan ekspresi negatif 17 (37%) dari 46 pasien, dengan pcmbagian pada tipe agresif terdapat 23 (50%) dari 46 pasien dan tipe non agresif 12 (26%) dari 46. Ekspresi Ki-67 negatif pada tipe agresif scbanyak 6 (13%) dari 46 pasien dan 5 (11%) dari 46 pasien tipe non-agresif. KSB tipe agresif menunjukkan ekspresi Ki-67 Iebih tinggi 79,31% dibandingkan dengan KSB tipe non agresif 70,59%_ Kesimpulan: KSB tipe agresif menunjukkan ekspresi Ki-67 lebih tinggi 79,31% dibandingkan dengan KSB tipe non agresif 70,59%. Hasil uji statistik diperoleh p value 0.097. Ada perbedaan proporsi kejadian KSB antara yang negatif dengan posititf Dari hasil analisis diperoleh OR l.597, artinya KSB agrcsif mempunyai peluang 1.597 kali dibanding dengan KSB non agrcsif <hr> <b>ABSTRACT</b><br> Purposed: To prove that aggressive type basal cel carcinoma shows Ki-67 expression higher than non aggressive type. Method: In this study obtained samples of 46 paraffin blocks of Dharmais Cancer Center that the criteria of inclusion from the year 1995-2008 to be assessed Ki-67 expression in histochemistry. Patient characteristics of the data analysis was performed by bivariate sample based on age groups, types of sex, type of histopathology. Result: Rcrata age ot`61 .30 += 11.97 years with a median of 61.50 years, Patient 24 years old the youngest and the oldest 84 years. Based on the results obtained ages of 16 Patient (34.8%) aged less than 60 years and 30 Patient (65.2%) aged more than or equal to 60 years. Distribution based on the type of sex from 46 Patient, 14 men (30.4%) and 32 women (69.6%). The results of expression of Ki-67 negative on aggressive type of 6 (13%) of 46 patients and 5 (11%) of 46 patients with non-aggressive type. Aggressive type of BCC, Ki-67 expression is higher by 79.31% compared to non-aggressive type of BCC 70.59%. Conclusion: Aggressive type of BCC, Ki-67 expression is higher by 79.31% compared to non-aggressive type of BCC 70.59%. Results obtained by statistical test p value of 0097. There is a difference between the proportion of negative events with BCC positive. The results of analysis OR 1597, that means aggressive BCC has chance BCC 1.597 times compared with non-aggressive.;Purposed: To prove that aggressive type basal cel carcinoma shows Ki-67 expression higher than non aggressive type. Method: In this study obtained samples of 46 paraffin blocks of Dharmais Cancer Center that the criteria of inclusion from the year 1995-2008 to be assessed Ki-67 expression in histochemistry. Patient characteristics of the data analysis was performed by bivariate sample based on age groups, types of sex, type of histopathology. Result: Rcrata age ot`61 .30 += 11.97 years with a median of 61.50 years, Patient 24 years old the youngest and the oldest 84 years. Based on the results obtained ages of 16 Patient (34.8%) aged less than 60 years and 30 Patient (65.2%) aged more than or equal to 60 years. Distribution based on the type of sex from 46 Patient, 14 men (30.4%) and 32 women (69.6%). The results of expression of Ki-67 negative on aggressive type of 6 (13%) of 46 patients and 5 (11%) of 46 patients with non-aggressive type. Aggressive type of BCC, Ki-67 expression is higher by 79.31% compared to non-aggressive type of BCC 70.59%. Conclusion: Aggressive type of BCC, Ki-67 expression is higher by 79.31% compared to non-aggressive type of BCC 70.59%. Results obtained by statistical test p value of 0097. There is a difference between the proportion of negative events with BCC positive. The results of analysis OR 1597, that means aggressive BCC has chance BCC 1.597 times compared with non-aggressive., Purposed: To prove that aggressive type basal cel carcinoma shows Ki-67 expression higher than non aggressive type. Method: In this study obtained samples of 46 paraffin blocks of Dharmais Cancer Center that the criteria of inclusion from the year 1995-2008 to be assessed Ki-67 expression in histochemistry. Patient characteristics of the data analysis was performed by bivariate sample based on age groups, types of sex, type of histopathology. Result: Rcrata age ot`61 .30 += 11.97 years with a median of 61.50 years, Patient 24 years old the youngest and the oldest 84 years. Based on the results obtained ages of 16 Patient (34.8%) aged less than 60 years and 30 Patient (65.2%) aged more than or equal to 60 years. Distribution based on the type of sex from 46 Patient, 14 men (30.4%) and 32 women (69.6%). The results of expression of Ki-67 negative on aggressive type of 6 (13%) of 46 patients and 5 (11%) of 46 patients with non-aggressive type. Aggressive type of BCC, Ki-67 expression is higher by 79.31% compared to non-aggressive type of BCC 70.59%. Conclusion: Aggressive type of BCC, Ki-67 expression is higher by 79.31% compared to non-aggressive type of BCC 70.59%. Results obtained by statistical test p value of 0097. There is a difference between the proportion of negative events with BCC positive. The results of analysis OR 1597, that means aggressive BCC has chance BCC 1.597 times compared with non-aggressive.]