Faktor-faktor yang berpengaruh terhadap keberhasilan fertillsasi in vitro di klinik Yamin RSUPN Cipto Mangunkusumo Januari 2006 - April 2008 = Factors infiuencing the survival of in vitro fertilization in Yasmin Clinic Cipto Mangunkusumo Hospital during January 2006-April 2008.
| Main Authors: | Siti Nadia, author, Add author: Tri Yunis Miko Wahyono, supervisor, Add author: Sudarto Ronoatmodjo, examiner, Add author: Tarigan, Lukman Hakim, examiner, Add author: Lukman Hendro Laksmono, examiner, Add author: Andon Hestiantoro, examiner |
|---|---|
| Format: | Masters Bachelors |
| Terbitan: |
, 2008
|
| Online Access: |
https://lib.ui.ac.id/detail?id=20339938 |
| ctrlnum |
20339938 |
|---|---|
| fullrecord |
<?xml version="1.0"?>
<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><type>Thesis:Masters</type><title>Faktor-faktor yang berpengaruh terhadap keberhasilan fertillsasi in vitro di klinik Yamin RSUPN Cipto Mangunkusumo Januari 2006 - April 2008 = Factors infiuencing the survival of in vitro fertilization in Yasmin Clinic Cipto Mangunkusumo Hospital during January 2006-April 2008.</title><creator>Siti Nadia, author</creator><creator>Add author: Tri Yunis Miko Wahyono, supervisor</creator><creator>Add author: Sudarto Ronoatmodjo, examiner</creator><creator>Add author: Tarigan, Lukman Hakim, examiner</creator><creator>Add author: Lukman Hendro Laksmono, examiner</creator><creator>Add author: Andon Hestiantoro, examiner</creator><publisher/><date>2008</date><subject/><description>[<b>ABSTRAK</b><br>
Latar belakang : Infertilitas masih menjadi masalah kesehatan masyarakat, hal ini
terkait dengan kompleksnya masalah dan akibat yang ditimbulkan pada pasutri yang
mengalami infertilitas. Pada saat ini berbagai teknologi dikembangkan untuk
pengobatan infertilitas, dimana salah satunya adalah fertilisasi in vitro. Mahalnya biaya
dan resiko keberhasilan yang rendah serta terbatasnya data epidemiologi tentang
keberhasilan fertilisasi in vitro di Indonesia membuat hal ini menarik untuk diteliti.
Tujuan : Mengetahui faktor-faktor yang berpengaruh terhadap keberhasilan (riwayat
kehami1an sebelumnya, lamanya infertil, lamanya perkawinan, usia isteri, cadangan sel
telur, obesitas, riwayat endometriosis, kebiasaan merokok pada isteri, infertilitas suami
dan teknik ICSI) kehamilan pasangan infertilitas yang melakukan fertilisasi in vitro di
klinik Yasmin, RSUPN Cipto Mangunkusumo pada tahun 2006-2008.
Desain Penelitian : Desain penelitian yang digunakan adalah kohort retrospektif,
dengan jumlah sampel sebanyak 129 pasangan yang melakukan fertilisasi in vitro tahun
2006-2008 di klinik Yasmin, RSUPN Cipto Mangunkusumo. Dalam melakukan analisa
data digunakan metode analisis kesintasan.
Hasil dan Diskusi : Angka Keberhasilan fertilisasi in vitro pada pasangan infertilitas
yang mengikuti program fertilisasi in vitro di Klinik Yasmin RSUPN Cipto
Mangunkusumo pada tahun 2006-2007 adalah sebesar 25,58% dengan angka insidens
6/1000 fertilisasi in vitro. Keseluruhan probabilitas keberhasilan pasangan infertilitas
yang mengikuti program fertilisasi in vitro di kIinik Yasmin RSUPN Cipto
Mangunkusumo adalab 16,99% (42 hari), 41,32% (56 hari), 74,78% (91 hari) dan
87,39% (127 hari) dengan median survival pada hari ke 66. Pada analisa multivariat
dengan menggunakan stratified cox model didapatkan adanya riwayat kehamilan
sebelumnya secara bermakna memiliki resiko keberhasilan kehamilan lebih tinggi
sebesar 2,13 kaH dibandingkan dengan wanita yang tidak memiliki riwayat kehamilan
sebelumnya (HR- 2.13 CI 1-4,5).
Kesimpulan dan saran: Masih rendahnya keberhasilan fertilisasi in vitro di klinik
Yasmin, RSUPN Cipto Mangunkusumo. Faktor yang berpengaruh pada keberhasilan
fertilisasi in vitro adalah adanya riwayat kehamilan sebelumnya. Dengan kata lain
infertilitas sekunder memiliki keberhasilan kehamilan lebih baik daripada infertilitas
primer. Keseluruhan probabilitas keberhasilan pasangan infertilitas yang mengikuti
program fertilisasi in vitro di klinik Yasmin RSUPN Cipto Mangunkusumo tahun 2006-
2008 adalah 16,99% (42 hari), 74,78% (91 hari) dan 87,39% (127 hari) dengan median
survival pada hari ke 66. Untuk semakin meningkatkan angka keberhasilan fertilisasi in
vitro perIu adanya perbaikan kualitas pengobatan fertilisasi in vitro melalui standarisasi
rekam medis, peningkatan kemampuan SDM, peralatan, teknik dan standard
penatalaksanaan.
<hr>
<b>ABSTRACT</b><br>
Background: The infertility is still public health problem since the impact of infertility
involve many factors and more complex. Currently new technology are developed to
treat the infertility problem including in vitro fertilization. However, high cost with low
success rate and limited evidenced in epidemiology study on the in vitro fertilization
treatment is interesting to be discussed further.
ObJective: This study was undertaken to assess the influence factors (specifically on
age, history of previous pregnancy, duration of infertile, duration of marriage, obesity,
endometriosis, smoking, male infertility, ovarian reserved, ICSI technique) from
infertile couples who underwent in vitro fertilization treatment in Yasmin clinic, Cipto
Mangunlrusumo Hospital in 2006-2008.
Design: Retrospective cohort was performed in this study. Clinical pregnancy after
IVF treatment were assessed and 129 eligible infertile couples were followed
retrospectively. Survival analysis was perfonned to estimate the cumulative probability
of pregnancy. Stratified cox regression was used for assessing the effects of factors
influencing the pregnancy rate.
Result : During 2006-2008 the pregnancy rate was 25.58% with the incidence rate
6/1000 in vitro fertilization. Probability survival of on going pregnancy infertile couples
undergoing IVF was 16.99% (day 42), 41.32% (day 56), 74.78% (day 91) dan 87.39%
(day 127) with median survival was on day 66. Infertile couples with history of
previous pregnancy had a significantly higher on survival ongoing pregnancy rate than
infertile couples with no previous pregnancy with multivariate Hazard ratio ( HR) of
2.13 (HR=2.13 CI 1.00-4.5).
Conclusion: The clinical pregnancy rate during 2006-2008 found in Yasmin Clinic,
Cipto Mangunkusumo Hospital still low. The most influenced factors on survival
clinical pregnancy is infertile couples with history of previous pregnancy. It is
necessary to improve the in vitro fertilization treatment in order to achieve higher
probability of ongoing pregnancy rate by improvement of human capacity, techniques
required, improvement in medical records, equipments and standard of operating
procedures.;Background: The infertility is still public health problem since the impact of infertility
involve many factors and more complex. Currently new technology are developed to
treat the infertility problem including in vitro fertilization. However, high cost with low
success rate and limited evidenced in epidemiology study on the in vitro fertilization
treatment is interesting to be discussed further.
ObJective: This study was undertaken to assess the influence factors (specifically on
age, history of previous pregnancy, duration of infertile, duration of marriage, obesity,
endometriosis, smoking, male infertility, ovarian reserved, ICSI technique) from
infertile couples who underwent in vitro fertilization treatment in Yasmin clinic, Cipto
Mangunlrusumo Hospital in 2006-2008.
Design: Retrospective cohort was performed in this study. Clinical pregnancy after
IVF treatment were assessed and 129 eligible infertile couples were followed
retrospectively. Survival analysis was perfonned to estimate the cumulative probability
of pregnancy. Stratified cox regression was used for assessing the effects of factors
influencing the pregnancy rate.
Result : During 2006-2008 the pregnancy rate was 25.58% with the incidence rate
6/1000 in vitro fertilization. Probability survival of on going pregnancy infertile couples
undergoing IVF was 16.99% (day 42), 41.32% (day 56), 74.78% (day 91) dan 87.39%
(day 127) with median survival was on day 66. Infertile couples with history of
previous pregnancy had a significantly higher on survival ongoing pregnancy rate than
infertile couples with no previous pregnancy with multivariate Hazard ratio ( HR) of
2.13 (HR=2.13 CI 1.00-4.5).
Conclusion: The clinical pregnancy rate during 2006-2008 found in Yasmin Clinic,
Cipto Mangunkusumo Hospital still low. The most influenced factors on survival
clinical pregnancy is infertile couples with history of previous pregnancy. It is
necessary to improve the in vitro fertilization treatment in order to achieve higher
probability of ongoing pregnancy rate by improvement of human capacity, techniques
required, improvement in medical records, equipments and standard of operating
procedures., Background: The infertility is still public health problem since the impact of infertility
involve many factors and more complex. Currently new technology are developed to
treat the infertility problem including in vitro fertilization. However, high cost with low
success rate and limited evidenced in epidemiology study on the in vitro fertilization
treatment is interesting to be discussed further.
ObJective: This study was undertaken to assess the influence factors (specifically on
age, history of previous pregnancy, duration of infertile, duration of marriage, obesity,
endometriosis, smoking, male infertility, ovarian reserved, ICSI technique) from
infertile couples who underwent in vitro fertilization treatment in Yasmin clinic, Cipto
Mangunlrusumo Hospital in 2006-2008.
Design: Retrospective cohort was performed in this study. Clinical pregnancy after
IVF treatment were assessed and 129 eligible infertile couples were followed
retrospectively. Survival analysis was perfonned to estimate the cumulative probability
of pregnancy. Stratified cox regression was used for assessing the effects of factors
influencing the pregnancy rate.
Result : During 2006-2008 the pregnancy rate was 25.58% with the incidence rate
6/1000 in vitro fertilization. Probability survival of on going pregnancy infertile couples
undergoing IVF was 16.99% (day 42), 41.32% (day 56), 74.78% (day 91) dan 87.39%
(day 127) with median survival was on day 66. Infertile couples with history of
previous pregnancy had a significantly higher on survival ongoing pregnancy rate than
infertile couples with no previous pregnancy with multivariate Hazard ratio ( HR) of
2.13 (HR=2.13 CI 1.00-4.5).
Conclusion: The clinical pregnancy rate during 2006-2008 found in Yasmin Clinic,
Cipto Mangunkusumo Hospital still low. The most influenced factors on survival
clinical pregnancy is infertile couples with history of previous pregnancy. It is
necessary to improve the in vitro fertilization treatment in order to achieve higher
probability of ongoing pregnancy rate by improvement of human capacity, techniques
required, improvement in medical records, equipments and standard of operating
procedures.]</description><identifier>https://lib.ui.ac.id/detail?id=20339938</identifier><recordID>20339938</recordID></dc>
|
| format |
Thesis:Masters Thesis Thesis:Bachelors |
| author |
Siti Nadia, author Add author: Tri Yunis Miko Wahyono, supervisor Add author: Sudarto Ronoatmodjo, examiner Add author: Tarigan, Lukman Hakim, examiner Add author: Lukman Hendro Laksmono, examiner Add author: Andon Hestiantoro, examiner |
| title |
Faktor-faktor yang berpengaruh terhadap keberhasilan fertillsasi in vitro di klinik Yamin RSUPN Cipto Mangunkusumo Januari 2006 - April 2008 = Factors infiuencing the survival of in vitro fertilization in Yasmin Clinic Cipto Mangunkusumo Hospital during January 2006-April 2008. |
| publishDate |
2008 |
| url |
https://lib.ui.ac.id/detail?id=20339938 |
| contents |
[<b>ABSTRAK</b><br>
Latar belakang : Infertilitas masih menjadi masalah kesehatan masyarakat, hal ini
terkait dengan kompleksnya masalah dan akibat yang ditimbulkan pada pasutri yang
mengalami infertilitas. Pada saat ini berbagai teknologi dikembangkan untuk
pengobatan infertilitas, dimana salah satunya adalah fertilisasi in vitro. Mahalnya biaya
dan resiko keberhasilan yang rendah serta terbatasnya data epidemiologi tentang
keberhasilan fertilisasi in vitro di Indonesia membuat hal ini menarik untuk diteliti.
Tujuan : Mengetahui faktor-faktor yang berpengaruh terhadap keberhasilan (riwayat
kehami1an sebelumnya, lamanya infertil, lamanya perkawinan, usia isteri, cadangan sel
telur, obesitas, riwayat endometriosis, kebiasaan merokok pada isteri, infertilitas suami
dan teknik ICSI) kehamilan pasangan infertilitas yang melakukan fertilisasi in vitro di
klinik Yasmin, RSUPN Cipto Mangunkusumo pada tahun 2006-2008.
Desain Penelitian : Desain penelitian yang digunakan adalah kohort retrospektif,
dengan jumlah sampel sebanyak 129 pasangan yang melakukan fertilisasi in vitro tahun
2006-2008 di klinik Yasmin, RSUPN Cipto Mangunkusumo. Dalam melakukan analisa
data digunakan metode analisis kesintasan.
Hasil dan Diskusi : Angka Keberhasilan fertilisasi in vitro pada pasangan infertilitas
yang mengikuti program fertilisasi in vitro di Klinik Yasmin RSUPN Cipto
Mangunkusumo pada tahun 2006-2007 adalah sebesar 25,58% dengan angka insidens
6/1000 fertilisasi in vitro. Keseluruhan probabilitas keberhasilan pasangan infertilitas
yang mengikuti program fertilisasi in vitro di kIinik Yasmin RSUPN Cipto
Mangunkusumo adalab 16,99% (42 hari), 41,32% (56 hari), 74,78% (91 hari) dan
87,39% (127 hari) dengan median survival pada hari ke 66. Pada analisa multivariat
dengan menggunakan stratified cox model didapatkan adanya riwayat kehamilan
sebelumnya secara bermakna memiliki resiko keberhasilan kehamilan lebih tinggi
sebesar 2,13 kaH dibandingkan dengan wanita yang tidak memiliki riwayat kehamilan
sebelumnya (HR- 2.13 CI 1-4,5).
Kesimpulan dan saran: Masih rendahnya keberhasilan fertilisasi in vitro di klinik
Yasmin, RSUPN Cipto Mangunkusumo. Faktor yang berpengaruh pada keberhasilan
fertilisasi in vitro adalah adanya riwayat kehamilan sebelumnya. Dengan kata lain
infertilitas sekunder memiliki keberhasilan kehamilan lebih baik daripada infertilitas
primer. Keseluruhan probabilitas keberhasilan pasangan infertilitas yang mengikuti
program fertilisasi in vitro di klinik Yasmin RSUPN Cipto Mangunkusumo tahun 2006-
2008 adalah 16,99% (42 hari), 74,78% (91 hari) dan 87,39% (127 hari) dengan median
survival pada hari ke 66. Untuk semakin meningkatkan angka keberhasilan fertilisasi in
vitro perIu adanya perbaikan kualitas pengobatan fertilisasi in vitro melalui standarisasi
rekam medis, peningkatan kemampuan SDM, peralatan, teknik dan standard
penatalaksanaan.
<hr>
<b>ABSTRACT</b><br>
Background: The infertility is still public health problem since the impact of infertility
involve many factors and more complex. Currently new technology are developed to
treat the infertility problem including in vitro fertilization. However, high cost with low
success rate and limited evidenced in epidemiology study on the in vitro fertilization
treatment is interesting to be discussed further.
ObJective: This study was undertaken to assess the influence factors (specifically on
age, history of previous pregnancy, duration of infertile, duration of marriage, obesity,
endometriosis, smoking, male infertility, ovarian reserved, ICSI technique) from
infertile couples who underwent in vitro fertilization treatment in Yasmin clinic, Cipto
Mangunlrusumo Hospital in 2006-2008.
Design: Retrospective cohort was performed in this study. Clinical pregnancy after
IVF treatment were assessed and 129 eligible infertile couples were followed
retrospectively. Survival analysis was perfonned to estimate the cumulative probability
of pregnancy. Stratified cox regression was used for assessing the effects of factors
influencing the pregnancy rate.
Result : During 2006-2008 the pregnancy rate was 25.58% with the incidence rate
6/1000 in vitro fertilization. Probability survival of on going pregnancy infertile couples
undergoing IVF was 16.99% (day 42), 41.32% (day 56), 74.78% (day 91) dan 87.39%
(day 127) with median survival was on day 66. Infertile couples with history of
previous pregnancy had a significantly higher on survival ongoing pregnancy rate than
infertile couples with no previous pregnancy with multivariate Hazard ratio ( HR) of
2.13 (HR=2.13 CI 1.00-4.5).
Conclusion: The clinical pregnancy rate during 2006-2008 found in Yasmin Clinic,
Cipto Mangunkusumo Hospital still low. The most influenced factors on survival
clinical pregnancy is infertile couples with history of previous pregnancy. It is
necessary to improve the in vitro fertilization treatment in order to achieve higher
probability of ongoing pregnancy rate by improvement of human capacity, techniques
required, improvement in medical records, equipments and standard of operating
procedures.;Background: The infertility is still public health problem since the impact of infertility
involve many factors and more complex. Currently new technology are developed to
treat the infertility problem including in vitro fertilization. However, high cost with low
success rate and limited evidenced in epidemiology study on the in vitro fertilization
treatment is interesting to be discussed further.
ObJective: This study was undertaken to assess the influence factors (specifically on
age, history of previous pregnancy, duration of infertile, duration of marriage, obesity,
endometriosis, smoking, male infertility, ovarian reserved, ICSI technique) from
infertile couples who underwent in vitro fertilization treatment in Yasmin clinic, Cipto
Mangunlrusumo Hospital in 2006-2008.
Design: Retrospective cohort was performed in this study. Clinical pregnancy after
IVF treatment were assessed and 129 eligible infertile couples were followed
retrospectively. Survival analysis was perfonned to estimate the cumulative probability
of pregnancy. Stratified cox regression was used for assessing the effects of factors
influencing the pregnancy rate.
Result : During 2006-2008 the pregnancy rate was 25.58% with the incidence rate
6/1000 in vitro fertilization. Probability survival of on going pregnancy infertile couples
undergoing IVF was 16.99% (day 42), 41.32% (day 56), 74.78% (day 91) dan 87.39%
(day 127) with median survival was on day 66. Infertile couples with history of
previous pregnancy had a significantly higher on survival ongoing pregnancy rate than
infertile couples with no previous pregnancy with multivariate Hazard ratio ( HR) of
2.13 (HR=2.13 CI 1.00-4.5).
Conclusion: The clinical pregnancy rate during 2006-2008 found in Yasmin Clinic,
Cipto Mangunkusumo Hospital still low. The most influenced factors on survival
clinical pregnancy is infertile couples with history of previous pregnancy. It is
necessary to improve the in vitro fertilization treatment in order to achieve higher
probability of ongoing pregnancy rate by improvement of human capacity, techniques
required, improvement in medical records, equipments and standard of operating
procedures., Background: The infertility is still public health problem since the impact of infertility
involve many factors and more complex. Currently new technology are developed to
treat the infertility problem including in vitro fertilization. However, high cost with low
success rate and limited evidenced in epidemiology study on the in vitro fertilization
treatment is interesting to be discussed further.
ObJective: This study was undertaken to assess the influence factors (specifically on
age, history of previous pregnancy, duration of infertile, duration of marriage, obesity,
endometriosis, smoking, male infertility, ovarian reserved, ICSI technique) from
infertile couples who underwent in vitro fertilization treatment in Yasmin clinic, Cipto
Mangunlrusumo Hospital in 2006-2008.
Design: Retrospective cohort was performed in this study. Clinical pregnancy after
IVF treatment were assessed and 129 eligible infertile couples were followed
retrospectively. Survival analysis was perfonned to estimate the cumulative probability
of pregnancy. Stratified cox regression was used for assessing the effects of factors
influencing the pregnancy rate.
Result : During 2006-2008 the pregnancy rate was 25.58% with the incidence rate
6/1000 in vitro fertilization. Probability survival of on going pregnancy infertile couples
undergoing IVF was 16.99% (day 42), 41.32% (day 56), 74.78% (day 91) dan 87.39%
(day 127) with median survival was on day 66. Infertile couples with history of
previous pregnancy had a significantly higher on survival ongoing pregnancy rate than
infertile couples with no previous pregnancy with multivariate Hazard ratio ( HR) of
2.13 (HR=2.13 CI 1.00-4.5).
Conclusion: The clinical pregnancy rate during 2006-2008 found in Yasmin Clinic,
Cipto Mangunkusumo Hospital still low. The most influenced factors on survival
clinical pregnancy is infertile couples with history of previous pregnancy. It is
necessary to improve the in vitro fertilization treatment in order to achieve higher
probability of ongoing pregnancy rate by improvement of human capacity, techniques
required, improvement in medical records, equipments and standard of operating
procedures.] |
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IOS18064.20339938 |
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Universitas Indonesia |
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51 |
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library:university library |
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Perpustakaan Universitas Indonesia |
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492 |
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Repository Skripsi (open) Universitas Indonesia |
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18064 |
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KOTA DEPOK |
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JAWA BARAT |
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IOS18064 |
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2022-12-13T09:09:17Z |
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2022-12-13T09:09:17Z |
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dc |
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1752099256618975232 |
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17.538404 |