Comparison of Lactulose plus Rifaxamin versus Lactulose Alone For Hepatic Encephalopathy
| Main Authors: | Attia Riaz, Khadeeja Mustafa, Rabia Saeed |
|---|---|
| Format: | Article info application/pdf Journal |
| Bahasa: | eng |
| Terbitan: |
IJHS Medical Association
, 2021
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| Subjects: | |
| Online Access: |
https://www.ijhsonline.com/index.php/IJHS/article/view/229 https://www.ijhsonline.com/index.php/IJHS/article/view/229/158 |
Daftar Isi:
- Objective;Comparison of lactulose plus Rifaxamin versus lactulose alone for hepatic encephalopathy. Patients and methods:this was a randomized control trial conducted at Service Hospital, Lahore. In the present study, the cases of hepatic encephalopathy of both genders having age of 30 to 70 years were included. The diagnosis of hepatic encephalopathy was made according to the West Haven Criteria and cases were divided into four groups accordingly. The group A was given Lactulose in the form of syrups in a dose of 30 ml three times a day and Rifaxamin in a dose of 550 mg twice daily while in group B, the lactulose only was given in a dose of 30 ml three times a day. Efficacy was labelled as yes where there were no signs and symptoms of hepatic encephalopathy. Results;In the present study 100 cases of hepatic encephalopathy (50 in each group) were selected with mean age of 47.43± 7.21 years in group A and 51.24±9.28 years in group B. In Group A, there were 31 (62%) males and in group B there were 30 (60%) males and the rest were females. There were 28 (56%) cases in Child pugh class C in group A and 31 (62%) in group B with no significant difference (p=0.34). There was also no difference in terms of grade of hepatic encephalopathy in both the groups with p= 0.57. There was significant difference in outcome in the form of efficacy which was seen in 36 (72%) in group A and 29 (58%) in group B while mortality in 14 (28%) in group A and 21 (42%) n group B respectively with p values of 0.01 in each group. Conclusion; Hepatic encephalopathy can be fatal. The combination of Rifaxamin and Lactulose has shown significant better difference both in term of mortality as well as efficacy.