Platelet-Rich Fibrin (PRF) Gel as a Medium for Local Drug Delivery of Metronidazole
| Main Author: | Tripthi .P.S, S. Girish Rao and Preethi Bhat |
|---|---|
| Format: | Article info application/pdf Journal |
| Bahasa: | eng |
| Terbitan: |
IJHS Medical Association
, 2014
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| Subjects: | |
| Online Access: |
https://www.ijhsonline.com/index.php/IJHS/article/view/21 https://www.ijhsonline.com/index.php/IJHS/article/view/21/60 |
Daftar Isi:
- PurposeTo evaluate the efficiency of PRF gel as a vehicle for local drug delivery of Metronidazole to prevent theinfection of the operated site thereby eliminating the systemic loading of the body with antibiotics and evaluatethe effect of the PRF gel Infused with Metronidazole on soft tissue healing and bone regeneration andmaturation in extraction sockets following trans-alveolar extractions.Material and MethodsPRF gel infused with Metronidazole was inserted into bilateral trans-alveolar extraction sockets of mandibularthird molars test sites of sixty three patients. The bone regeneration rate was assessed radio graphically at 1week to 6 months and compared with that of the control group at same intervals. Soft tissue healing wasassessed clinically at every follow up and recorded in a questionnaire for the same.ResultsBetween July 2010 to March 2012, 63 patients were included in the study. Patients included 19 women (30%)and 44 men (70%) with a mean age of 25 years. The present study clearly indicates a significant improvement inthe regeneration of bone after third molar surgery in test sites treated with PRF gel with metronidazole ascompared to the control group post operatively with significant infection control and accelerated soft tissuehealing of the same.ConclusionThrough our study we derived the conclusion that platelet rich fibrin gel with metronidazole improved woundhealing during the 1st week after surgery owing to maximum growth factor concentration and antibiotic actionfor the first 5-7 days. It was also observed that significant improvement in bone regeneration (reduction indefect size) occurred over the entire course of healing as evident by the rapid and more complete bone growthobserved in the test group patients.