Multidrug-resistant Hospital-associated Infections in pediatric intensive care units
| Main Authors: | Iman khaled Eyada, Bassant Meligy, Dalia Kadry Ismail |
|---|---|
| Format: | Article info application/pdf Journal |
| Bahasa: | eng |
| Terbitan: |
IJHS Medical Association
, 2016
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| Subjects: | |
| Online Access: |
https://www.ijhsonline.com/index.php/IJHS/article/view/121 https://www.ijhsonline.com/index.php/IJHS/article/view/121/35 |
Daftar Isi:
- Background. The enormous burden that multi-drug resistant hospital acquired infection (MDR- HAI) lay on the lives in pediatric intensive care unit (PICU) in developing countries is scarcely studied. The present study was conducted to assess the incidence, epidemiological profile, underlying risk factors and outcome of children in PICU infected with MDR- HAI Methods.This is a prospective cohort study conducted in 2 pediatric intensive care units in Cairo University Pediatric hospital. The study was conducted from 1st January 2015 to 1st of January 2016. All children who developed HAI defined, according to the CDC were included in the study. ResultsThe present study encompassed 378 patient admitted to the intensive care over a period of twelve months. 57 patients developed 106 episodes of infection, making the incidence of HAI 28%. Ages were between 1- 144 months. (56.1%) were males while 25 (43.0%) were females. The number of infection episodes was 106 (range 1 – 7, with mean + SD 1.6 – 1.1). 98 were MDR infections, while 8 were non-MDR organisms. The incidence of MDR-HAI was 92.45% Infection with gram negative strains occurred in 89 (83.9%) of cases, while gram positive infections occurred in 17 (16.19%) cases. Acinetobacter spp (26.4% ), and Pseudomonas spp (25.5%) were the most common gram negative infections. VAP occurred in 55 cases (51.9%), BSI occurred in 17 (16.0%) cases, while CLBSI occurred in 16 (15.2%), HAP in 7 (6.6%) surgical wound infection in 5 (4.7%), CRUTI in 4 (3.8%) and VP shunt infection in 2 (1.9%) .The insertion of ETT was statistically significant for the development of MDR-HAI (P value 0.049). Klebsiella was significantly related to non-MDR infection (p value < 0.001) Conclusion:The incidence rate of MDR-HAI was alarming with high mortality rate. Gram negative bacteria were the most common organisms causing the infection with VAP being the most commonly prevalent. The insertion of ETT was a risk factor for MDR-HAI. The presence of malnutrition associated with MDR-HAI heralded mortality.