SINTESIS ANALOG 4-BROMO PIRAZOLIN DARI KALKON INTI NAFTALEN DENGAN KATALIS ASAM DAN UJI AKTIVITAS NYA SEBAGAI ANTIBAKTERI
| Main Authors: | Hariyanti, Desy, Teruna, Hilwan Yuda, ', Jasril |
|---|---|
| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam
, 2014
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| Online Access: |
http://jom.unri.ac.id/index.php/JOMFMIPA/article/view/3598 http://jom.unri.ac.id/index.php/JOMFMIPA/article/view/3598/3492 |
Daftar Isi:
- Pyrazolines have been reported to possess various biological activities such as antimicrobial, antidepressant, antidiabetic, anti-inflammatory, antipyretic, anticancer, and anticonvulsant activity. In this research, a halogenated pirazoline 5-(4-bromophenyl)-3-(naphthalene-1-yl)-4,5-dihydro-1H-pyrazole was synthesized by cyclization reaction between chalchone with hydrazine hydrate using acetate acid as catalyst under microwave irradiation. The compound showed a good yield, and then was characterized by UV, IR, 1H-NMR, and 13C-NMR spectroscopy. The antibacterial activity of pyrazolines was determined using the agar diffusion method against Gram-negative bacteria: Escherichia coli and Salmonella typhi and Gram-positive bacteria: Bacillus subtilis and Staphylococcus aureus. This compound showed inhibitory activity against those four bacteria. Test results of antibacterial activity indicated that pyrazoline analogues were potential as antibiotics.