SINTESIS DAN UJI AKTIVITAS ANTIBAKTERI DARI SENYAWA 1-FENIL-3-(1-NAFTIL)-5-(2-KLOROFENIL)-2-PIRAZOLIN
| Main Authors: | ', Dahliarti, Teruna, Hilwan Yuda, ', Jasril |
|---|---|
| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam
, 2014
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| Online Access: |
http://jom.unri.ac.id/index.php/JOMFMIPA/article/view/3553 http://jom.unri.ac.id/index.php/JOMFMIPA/article/view/3553/3448 |
Daftar Isi:
- Pyrazoline is a bioactive compound but it is rare in nature. Pyrazoline has bioactivitieswhich are anti-inflammantory, antimicrobial, antibacterial, antidiabetic and antipyreticactivity. In this study this compound has been synthesized by reacting phenylhydrazinewith (E)-3-(2-chlorophenyl)-1-(naphtalen-1-yl)prop-2-en-1-one chalcone and thencatalyzed by acetic acid using microwave irradiation method. The yield of 1-phenyl-3-(1-naphtyl)-5-(2-chlorophenyl)-2-pyrazoline compound was 76,23%. This pyrazolinewas characterized using UV-Vis, IR, 1 H-NMR and 13 C-NMR spectrometer. Bioactivitytest showed that the pyrazoline compound does not have antibacterial activity againtGram-positive and Gram-negative bacteria.