A Mini Review Clinically Significant Potential Drug-Drug Interactions In COVID-19 and Comorbid Therapy
| Main Authors: | Faizah, Ana Khusnul, Nurrahman, Nani Wijayanti Dyah, Putra, Oki Nugraha |
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| Format: | Book application/pdf Journal |
| Terbitan: |
UI Scholars Hub
, 2020
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| Subjects: | |
| Online Access: |
https://scholarhub.ui.ac.id/psr/vol7/iss4/3 https://scholarhub.ui.ac.id/cgi/viewcontent.cgi?article=1070&context=psr |
Daftar Isi:
- Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and can be aggravated by comorbid diseases. In administering COVID-19 therapy, we need to consider potential drug-drug interactions (pDDIs) with comorbid drugs. Most patients with comorbid diseases get polypharmacy, therefore the risk of pDDIs increases. Potential drug-drug interactions can cause unwanted effects such as toxicity to death. There is no on-label therapy for COVID-19 but FDA has Emergency Use Authorization (EUA) for hydroxychloroquine, chloroquine, azithromycin, remdesivir, ritonavir, and lopinavir. Some COVID-19 treatment potential drug-drug interactions have a level of severity C and D, so there is a high need for close monitoring during drug administration or modification therapy.