Low-Level Laser Therapy to the Major Salivary Glands Increases Salivary Flow and MUC5B Protein Secretion in Diabetic Patients with Hyposalivation: A Preliminary Study
| Main Authors: | Wibawa, Awaludin, Sucharitakul, Jeerus, Dansirikul, Rungthip, Pisarnturakit, Pagaporn P, Bhuridej, Patita, Arirachakaran, Pratanporn |
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| Format: | Book application/pdf Journal |
| Terbitan: |
UI Scholars Hub
, 2018
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| Subjects: | |
| Online Access: |
https://scholarhub.ui.ac.id/mjhr/vol22/iss1/3 https://scholarhub.ui.ac.id/cgi/viewcontent.cgi?article=1053&context=mjhr |
Daftar Isi:
- Background: To investigate the effect of low-level laser therapy to salivary gland function in diabetic patients with hyposalivation. Methods: Twelve diabetic patients were recruited. A 940-nm indium-gallium-arsenide-phosphide low-power semiconductor diode laser was used to stimulate the major salivary glands with an irradiation time of 40 s; this was done three times a week for 2 consecutive weeks. Patients were given questionnaires related to dry mouth symptoms. Salivary flow rates, questionnaire responses as well as MUC7, MUC5B and histatin 5 protein salivary concentrations were assessed at the first and sixth visits after laser therapy as well at the 6-week follow-up visit. Results: The unstimulated salivary flow rate and MUC5B concentration at the follow-up visit significantly increased (p < 0.01). Histatin 5 concentration significantly decreased at the follow-up visit compared with that at the first visit (p < 0.05). The mean dry mouth score revealed a significant decrease in dry mouth symptoms at the sixth visit and follow-up visit compared with those at the first visit (p < 0.001). The positive correlation between dry mouth score and flow rate was the strongest at the sixth visit (rs = 0.549). Conclusions: Low-level laser therapy increased the salivary flow rate and decreased dry mouth symptoms in diabetic patients.