Identifikasi Interaksi Kimia Fisika Pada Kombinasi Antibiotika Amoksisilina Trihidrat - Kalium Klavulanat Dengan Kalorimeter Larutan Dan Rekristalisasi
| Main Authors: | Nugrahani, Ilma, Asyarie, Sukmadjaja, N.S, Sundani, Ibrahim, Slamet |
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| Format: | Book application/pdf Journal |
| Terbitan: |
UI Scholars Hub
, 2007
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| Subjects: | |
| Online Access: |
https://scholarhub.ui.ac.id/mik/vol4/iss3/2 https://scholarhub.ui.ac.id/cgi/viewcontent.cgi?article=1052&context=mik |
Daftar Isi:
- Physico-chemical interaction of amoxicillin trihydrate - potassium clavulanate has been investigated. The method used in this experiment was solution calorimeter analysis that was collaborated by the re-crystallization observation. Amoxicillin-clavulanate were mixed on the variety ratios (0:10; 9:1; ...; 1:9; 0:10) and analyzed by solution calorimeter in the HCl 0,1 N and phosphate buffer pH 6,8 solution as the gastrointestinal liquids. After that, the re-crystallizations of amoxicillin-clavulanate on the variety ratios were analyzed by polarization microscope and digital camera. The results of observation showed that amoxicillin-clavulanate have the physical-chemical interactions in the ratios 3:7; 5:5; 7:3 respectively in both of pH models of gastrointestinal liquids.