Potential Local And Systemic effects of microplasTICS upon ingestion - PLASTICS
| Main Author: | Steeg, E.vande |
|---|---|
| Other Authors: | Kooter, I.K |
| Format: | info Lainnya eJournal |
| Terbitan: |
, 2020
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/4118262 |
Daftar Isi:
- Microplastics are a new type of environmental pollutant and are very prevalent in our environment. Microplastics may affect human health through multiple routes e.g. by the food chain or by inhalation. It is unclear as to what extent human exposure to environmental small plastic particles of varying shape, size and composition is a health threat. As microplastics are easily ingested, the intestinal mucosa is continuously being exposed to the microplastics. Our projects aims to determine the potential hazard of consuming small plastic particles of varying shape, size and composition by studying the potential systemic exposure of these small plastic particles by determining intestinal absorption and transport. A subset of microplastics will be exposed to the physiologically relevant InTESTine system and intestinal absorption will be determined as well as toxicologic parameters will be measured by studying the viability and integrity as well as the local inflammatory responses.