A REVIEW ON NEW OFLOXACIN-FLUOROQUINOLONE ANALOGS: SYNTHESIS AND BIOLOGICAL EVALUATION OF DIFFERENT COMPOUNDS
| Main Author: | Ramakrishna.C 1*, Subba Reddy.G.V 2 |
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| Format: | Article eJournal |
| Terbitan: |
, 2020
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/4010270 |
Daftar Isi:
- Fluoroquinolones are important antimicrobial agents that have demonstrated activity against a wide range of Gram-positive and Gram-negative organisms and have proved useful against micro-organisms that are resistant to other antibacterial agents. Examples are Gatifloxacin, moxifloxacin, ofloxacin, pefloxacin, levofloxacin with new ones entering the market. This review is focused on fluoroquinolone especially ofloxacin. Quinolones, that all the clinically useful bear a fluorine group at the C-6 position and such quinolones are described as fluoroquinolones. They have a very good pharmacokinetic profiles and attain appreciable concentrations well above their MIC’s in biological tissues. The fluoroquinolones have been analyzed by various methods which have been described in different works of literature. This review needful in fluoroquinolone research and development, both in bulk and pharmaceutical dosage forms as well as their determination in biological fluids. However, increased prescribing has led to the recent emergence of fluoroquinolone-resistant bacteria which has necessitated the search of newer drugs with efficacy against resistant strains and efforts are on worldwide in this direction. The present review explores active ofloxacin derivatives having different biological activities published during the last 15 years, also critical aspects of structures concerning to biological activities. The present work gives the potential use of novel ofloxacin and fluoroquinolone derivatives.