ДЕСКВАМИРОВАННЫЕ ЭНДОТЕЛИОЦИТЫ И ЭТАПЫ ИХ ДЕГРАДАЦИИ В КРОВИ У БОЛЬНЫХ ИШЕМИЧЕСКОЙ БОЛЕЗНЬЮ СЕРДЦА
| Main Authors: | Pavlega, A. E., Gozhenko, A. I., Kotiuzhynska, S. G., Badiuk, N. S., Vasyuk, V. L. |
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| Format: | Article eJournal |
| Terbitan: |
, 2020
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| Online Access: |
https://zenodo.org/record/3744386 |
Daftar Isi:
- Pavlega A. E., Gozhenko A. I., Kotiuzhynska S. G., Badiuk N. S., Vasyuk V. L. DESCAMED ENDOTHELIOCYTES AND STAGES OF THEIR DEGRADATION IN BLOOD IN PATIENTS WITH ISCHEMIC HEART DISEASE = ДЕСКВАМИРОВАННЫЕ ЭНДОТЕЛИОЦИТЫ И ЭТАПЫ ИХ ДЕГРАДАЦИИ В КРОВИ У БОЛЬНЫХ ИШЕМИЧЕСКОЙ БОЛЕЗНЬЮ СЕРДЦА. Актуальні проблеми транспортної медицини / Actual problems of transport medicine / 2020;1(59):87-93. ISSN 1818-9385 DOI http://dx.doi.org/10.5281/zenodo.3744386 http://aptm.org.ua DESCAMED ENDOTHELIOCYTES AND STAGES OF THEIR DEGRADATION IN BLOOD IN PATIENTS WITH ISCHEMIC HEART DISEASE A. E. Pavlega1, A. I. Gozhenko1, S. G. Kotiuzhynska2, N. S. Badiuk1, V. L. Vasyuk3 1Ukrainian Research Institute of Transport Medicine, Odessa, Ukraine 2Odessa National Medical University, Odessa, Ukraine 3Bukovinian State Medical University Summary The development of the diagnosis of vascular complications associated with endothelial dysfunction is an urgent task of modern medicine. The results of a fairly large number of studies have shown that the level of desquamated endothelial cells in the peripheral blood is a reflection of systemic endothelial damage, and allow us to consider desquamated endothelial cells (DEC) as specific markers of damage to the inner lining of blood vessels in various pathological conditions. The aim of the study was to analyze the content of DEC, a marker of the state of the vascular wall, in blood plasma in patients with cardiovascular pathology. Materials and methods. The study was conducted in 78 patients with a clinical diagnosis of coronary artery disease aged 49 to 62 years, who are on an outpatient basis in the family medicine outpatient clinic of the National Clinical Hospital No. 3 of Odessa. Counting DEC (cells / ml) was carried out according to the method of J. Hladovec (1978) as modified by Petrishchev N.N. et al. (2001). The results of the study. As a result of studies, it was found that at the same time as a reliable change in the amount of DEC in the blood by 1.5 times relative to the control data, the ratio of their various types at the stages of degradation also changed. Thus, a significant increase in the level of DEC in the second (expressed) stage was observed in all study groups (6.7 and 8.8 times, respectively) against the background of a moderate increase in the number of DEC relative to the initial and final stages. It should be noted that in groups of patients with coronary heart disease, both in men and in women, the changes did not differ significantly from each other. Conclusions. The revealed changes in the cell ratio at the stages of degradation in patients are important criteria for the functional of morph state of the endothelial system and allow us to use data for the early diagnosis of endothelial dysfunction in patients with cardiovascular pathology. Key words: endotheliocytes, coronary heart disease, endothelial dysfunction, cardiovascular pathology