A Review on Synthesis and Potential Biological Activities of Benzimidazole Derivatives: An Important Scaffold in Drug Discovery
| Main Authors: | Mohammad Asif, Abida, Md Tauquir Alam |
|---|---|
| Format: | Article eJournal |
| Terbitan: |
, 2020
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/3670007 |
Daftar Isi:
- The uses heterocyclic ring containing compounds in medicinal chemistry is escalating day by day due to heterocyclic rings are included in the many biologically active compounds, which are necessary for life like proteins, nucleic acid and carbohydrates, natural pigments like chlorophyll, vitamins, and antibiotics and also in most of the drugs, pesticides and dyes. Benzimidazoleas is a versatile heterocycle compound possessing diverse types of biological activities like antiulcer, antimicrobial, antipsychotic, antiprotozoal, antihelminthic, anti-allergic, antiviral, antineoplastic and other useful pharmacological activities. Although due to problems like resistance and toxicity, there is a need for modification of existing agents and to design new agents which include benzimidazole pharmacophore. This review focuses the use of Benzimidazole in medicinal chemistry. It also concerned about the chemistry of benzimidazole synthesis and reactions.