The Link Between Chronic Periodontitis and Head and Neck Squamous Cell Carcinoma: A Short Review
| Main Authors: | HiralBulsara, NupoorKulkarni, Shagun Modi, Akash Mankare, Muktai Deshpande, Gabriela Fernandes |
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| Format: | Article eJournal |
| Terbitan: |
, 2019
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/3589353 |
Daftar Isi:
- Chronicperiodontitis is an inflammatory condition characterised by the loss of attachment and a pocket depth >3mm. The organisms involved in pathogenesis are Tanerella Forsythia, Aggregatibacter Actinomycetemcomitans, Porphyromonas Gingivalis, Fusobacterium Nucleatum, Prevotella Intermedia, Campylobacter Rectus. These organisms release various bacterial biomarkers and increase the amount of inflammatory cytokines into the saliva. Head and neck cancer is classified as one of the top ten most commonly occurring cancers in the world. Risk factors include alcohol and tobacco consumption, genetic factors etc. Like every foreign substance, the cancer cells are susceptible to the immune system macrophages and lymphocytes, that initiate the release of inflammatory cytokines into the tumour environment and begin angiogenesis. This gives the tumour cells sufficient nutrition to proliferate. Concurrently, the periodontal pocket acts as a reservoir of many micro-organisms including HPV (human papilloma virus). The bacterial biomarkers released by these organisms lead to suppression of tumour necrotic factor, thus allowing the tumour to proliferate. Many studies have been conducted to prove the association between periodontal disease and oral cancer. From these studies, it can be concluded that periodontal disease, along with history of smoking and tobacco consumption is a significant risk factor associated with the development of oral cancer. Keywords: Head and neck cancer, periodontal disease, inflammation