DESIGN AND SYNTHESIS OF SMALL MOLECULES CAPABLE OF BINDING TO β-AMYLOID PROTIEN FOR THE TREATMENT OF ALZHEIMER'S DISEASE
| Main Author: | R. Suneetha *, S.K. Godasu, b. Nagaveni, P. Raju |
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| Format: | Article eJournal |
| Terbitan: |
, 2019
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/3557312 |
Daftar Isi:
- ABSTRACT In the present study a hybrid molecule was designed and synthesised which contains a Benzothiazole moiety and cinnomoyl moiety. The first part was specifically chosen for the amyloid protein binding and the remaining part is for its anti-oxidant properties. The molecule was synthesised using a straight forward synthesis as shown in the scheme. In this study two such derivatives were synthesised and fully characterised spectroscopically. KEYWORDS: Alzheimer’s disease, β-Amyloid protien, Benzothiazole, Cinnomoyl.