Flavonoids from Herba epimedii Protect against MPP+-induced Toxicity in MES23.5 Cells
| Main Authors: | Li, Na, Jiang, Mingchun, Chen, Wenfang |
|---|---|
| Format: | Article eJournal |
| Bahasa: | eng |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/3350279 |
Daftar Isi:
- Flavonoids, the active components of Herba epimedii (HEP), exerts many pharmacological effects, such as improvement of neurological function and sexual dysfunction, anti-osteoporosis and treatment of cardiovascular diseases in China over the centuries. According to the Chinese Pharmacopoeia, icariin, epimedin B and baohuoside-1 are three major flavonoid compounds isolated from HEP. The present study aims to characterize the neuroprotective effects of total flavonoid fraction of HEP and its three major flavonoid compounds against 1-methyl-4-phenylpyridinium ion (MPP+)-induced neurotoxicity in MES23.5 cells. MTT assay showed that treatment with MPP+ significantly suppressed the cell viability. The effect could be respectively reversed by HEP, icariin, epimedin B and baohuoside-1 treatment in a dose-dependent manner. The present results provided the evidence that HEP and its main active compounds could protect against MPP+-induced neurotoxicity in dopaminergic MES23.5 cells.Read Complete Article at ijSciences: V72018031615 AND DOI: http://dx.doi.org/10.18483/ijSci.1615