Effect of regular exercise-induced apelin on dyslipidemia of type 2 diabetic rats
| Main Author: | Fahimeh Kazemi, Khosro Ebrahim, Saleh Zahedi Asl |
|---|---|
| Format: | Article eJournal |
| Bahasa: | pes |
| Terbitan: |
, 2016
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/3343037 |
Daftar Isi:
- ABSTRACT Background: Recently the role of apelin in improvement of dislipidemia has been known. The purpose of this study was to determine the effect of regular exercise-induced apelin on dyslipidemia of type 2 diabetic rats. Methods: Twenty eight diabetic male Wistar rats were divided into 3 groups: Non-diabetic (n=9), control diabetic (n=9) and trained diabetic (n=10). Type 2 diabetes was induced by injection of nicotinamide and streptozotocin. The aerobic training program included 8-week running on treadmill progressively for 45 min at a speed of 24 m/min and a 5% grade. After the period of training, plasma level of apelin and lipids (TC, HDL-C, LDL-C, VLDL-C, TG and FFA) were measured. One-way analysis of variance (ANOVA) was used for analyzing data and p<0.05 was considered to be statistically significant. Results: In trained diabetic compared with control diabetic group, a significant increase in apelin, a significant decrease in plasma level of LDL-C, VLDL-C and TG, an insignificant decrease in TC and FFA, and an insignificant increase in HDL-C were observed. Conclusion: Results of present study showed that increase in plasma level of apelin following regular exercise by inhibition of lipolysis and decrease of blood lipids can improve dyslipidemia of type 2 diabetic rats.