CO-ENZYME Q-10: PREVENTIVE EFFECTS IN INH INDUCED HEPATOTOXICITY IN ALBINO WISTAR RATS
| Main Author: | . Shahnaz Bano Menon, Abdul RahimMemon, Ashique Ali Arain, Samreen Ali Pandhiani4, Sadia Kazi |
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| Format: | Article eJournal |
| Terbitan: |
, 2018
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/2166702 |
Daftar Isi:
- Tuberculosis is a common disease of the sub-continent and most of the anti-tuberculosis drugs are hepatotoxic, INH (Isoniazid) being on the top in this regard. We tried to explore the heptoprotectiveaspects of the Q-10(Co-enzyme) in the current studyin rat model by artificially inducing the hepatotoxicity by INH. Albino Westar rats were purchased from Karachi (n=50) then devided into 5 equalgroups (A,B,C,D,E) and left for acclimatization for two weeks periods. GroupA was kept interventionfree as control while group B was induced withINH 100 mg/day orally(n=10) as negative control and others groups C.was given INH 100mg+CoQ 100mg/day orally (n=10),group D. INH 150+ CoQ 100mg/day orally (n=10) and E. INH 200mg+CoQ 100mg/day orally (n=10) . Blood samples were drawn after 1month interventional period and liver function test were performed and comparison was done between the mean values using ANOVA on SPSS version 22 .It was observed that there was statistically highly significant difference in serum concentrations of AST(0.00001),ALT(0.0007), LDH(0.000010, ALP(0.00001),GGT(0.0004) among the experimental group. Co-enzyme Q-10 possesses hepatoprotective properties against the INH induced hepatotoxicity in a concentration dependent manner. Key Words: ALT, AST, LDH, GGT.