Combination of platelet-rich plasma and stromal vascular fraction on the level of transforming growth factor-β in rat subjects experiencing deep dermal burn injury
| Main Authors: | Rachman Laidding, Sachraswaty, Josh, Fonny, Francisca, Francisca, Faruk, Muhammad, Sinapati Palissei, Andi, Satria, Bayu, Warsinggih, Warsinggih, Bukhari, Agussalim, Nassrum Massi, Muh, Asadul Islam, Andi |
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| Format: | Article PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
, 2020
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| Subjects: | |
| Online Access: |
http://repository.unhas.ac.id/id/eprint/5161/ |
Daftar Isi:
- Introduction: The combination of stromal vascular fraction (SVF) and platelet-rich plasma (PRP) is effective at increasing the concentration of growth factors including transforming growth factor-β (TGF-β). The increase in this growth factor is expected to accelerate the healing of burns. This study aims to determine the effect of giving a combination of SVFs and PRP on TGF-β levels in the healing process of deep dermal burns. Methods: This was an experimental study in 64 rats using a post-test control group design consisting of 1 group of SVFs and PRP combination injection treatment group, 1 group given a topical combination of SVFs and PRP, 1 group given Vaseline, and 1 control group. Results: There was a significant difference in TGF-β levels between the deep dermal burns group that was given a combination of SVFs and PRP injection and topical, the Vaseline group, and the control group with p-value <0.05. Conclusion: The combination of SVFs and PRP increases the level of TGF-β in the healing process of deep dermal burns.