Alterations in epigenetic systems in A-T neurodegeneration
| Main Authors: | Jiali Li, Karl Herrup |
|---|---|
| Format: | Article Journal |
| Terbitan: |
, 2013
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/886855 |
Daftar Isi:
- Ataxia telangiectasia (A-T) is a hereditary multisystemic disease resulting from mutations in the ATM gene. Progressive motor function loss as a typical neurological phenotype is resulted from notably degeneration of the Purkinje and granule cells of the cerebellar cortex. However, the molecular mechanism of A-T neurodegenerationis the most poorly understood. Our studies have demonstrated that nuclear accumulation of HDAC4-induced histone deacetylation and EZH-mediated H3K27 tri-methylation contribute to A-T neurodegeneration.
- Editorial | Biohelikon : Cell Biology