Risk assessment of non-developmental health effects of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and dioxins-like polychlorinated biphenyls in food
| Main Authors: | Hanberg, A., Öberg, M., Sand, S., Darnerud, P. O., Glynn, A. |
|---|---|
| Format: | Report Journal |
| Terbitan: |
, 2007
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/818182 |
Daftar Isi:
- The Swedish National Food Administration (NFA) and the Institute of Environmental Medicine at Karolinska Institutet have performed a risk assessment of nondevelopmental exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (dl- PCBs), as a scientific base for revision of the dietary advice regarding consumption of dioxin-contaminated fish in Sweden. The aim of the risk assessment is to identify the critical health effects on humans exposed to dioxins during childhood and adulthood, and, if possible, to obtain a tolerable exposure level for these stages in life. In this process, uncertainties in the scientific data have been weighed into different scenarios of extrapolation from animal risks to human risks. Moreover, human data have been used as far as possible in the assessment of risks at background levels of exposure. The risk assessment is one of several scientific inputs to the process of revision of fish consumption advisories performed by the Swedish NFA, and will be used by the risk managers during the development of the new advisory. In this process the weighing of risks connected to fish consumption against the benefits of fish consumption is important, and we believe that this risk assessment will give a valuable contribution to this analysis. The risk assessment is based on the earlier risk assessments performed by the EU [10, 16] and WHO [5]. The critical studies regarding risks due to exposure during childhood (not including breast milk exposure), adolescence and adulthood were extracted from these assessments and from the literature published after these assessments were performed. We focus on toxic effects due to exposure after birth (not including breast milk exposure), both in animals and humans. The report does not include in-depth information on chemistry and analytical methods, sources, environmental levels,
- SE; en; salomon.sand@slv.se