EFFECTS OF GARCINIA KOLA SEED POWDER ON SERUM LEVEL OF FSH, LH AND TESTOSTERONE OF MALE ALBINO RATS EXPOSED TO EXOGENOUS HORMONES ADMINISTRATION
| Main Authors: | Ibekwe, H. A, Essien, A. D, Essien, A, Akpet S.O |
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| Format: | Article Journal |
| Terbitan: |
, 2009
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/818001 |
Daftar Isi:
- The study was carried out to investigate the effect of Garcinia kola Seed Powder inclusions on serum levels of follicle stimulating hormone, Luteinizing hormone, and testosterone of male albino rats exposed to exogenous hormone (Menotrophin and Testosterone) administration. The study investigated the adnohypophyseal-gonadal hormone interactions in male Albino rats administered with exogenous hormone while receiving doses of Garcinia kola seed powder. The study was carried out in two phases. Phase one was the administration of exogenous hormones (Menotrophin and Testosterone) and 18 male albino rats assigned into three treatment groups of 6 rats each were used. Phase two of the study consists of administration of Garcinia kola seed powder in the same way as was done in phase one of the study. The experiment was terminated after 6 weeks of treatment. The result obtained showed a significant (P<0.05) increase in serum gonadotrophins and testosterone levels relative to control rats on administration of menotrophin but a decrease in serum testosterone and an increase in gonadotrophins on administration of exogenous testosterone. The feeding of Garcinia kola seed powder to the rats however, caused no-significant (P>0.05) increase in serum gonadotrophin but a significant (P<0.05) reduction in testosterone levels of male albino rats exposed to menotrophins. There was also significant (P<0.05) reduction in both serum gonadotrophin and testosterone levels of male albino rats exposed to exogenous testosterone. The findings of this study revealed that there seem to be negative feed back control on testosterone secretion by gonadotrophin in rats treated with Garcinia kola seed Powder and that the detrimental effect of Garcinia kola seed powder on the testis may not be reversed by administration of exogenous testosterone